Sodium dimercaptopropane sulfonate as antidote against non-metallic pesticides  

作　　者：Zhi-kangCHEN Zhong-qiuLU 

机构地区：[1]DepartmentofPharmacology,SchoolofPharmacy,WenzhouMedicalCollege,Wenzhou325035 [2]EmergencyDepartment,TheFirstAffiliatedHospitalofWenzhouMedicalCollege,Wenzhou325000,China

出　　处：《Acta Pharmacologica Sinica》2004年第4期534-544,共11页中国药理学报（英文版）

摘　　要：With the advent of World War II, dimercaptol was first developed in Englandas an effective antidote against arsenical agents. In 1950''s, scientists from the Soviet Uniondeveloped a water-soluble compound, sodium dimercaptopropane sulfonate (Na-DMPS) named as Unithiol(or Unitiol), which was able to chelate heavy metals and metalloids. Unithiol was collected in thePharmacopeia of the Soviet Union. After a lot of efforts of scientists from several countries, thisdrug has been widely used in the treatment of the poisoning of heavy metals and metalloids, as awell-known specific antidote. Considering the importance of sulfhydryl groups in human body, wefirst initiated the possibility of sulfhydryl compounds as antidotes against some non-metaltoxicants. In 1970''s, they screened many sulfhydryl compounds as antidotes against acute poisoningof nereistoxin insecticides (NTXI), and found that dithiol compounds were much better than monothiolcompounds in the treatment for NTXI poisoning. Na-DMPS and sodium dimercapto-succinate (Na-DMS)were among the best antidotes (Fig 1). The accumulation of experimental studies and clinical trialshas confirmed that they were specific effective antidotes against NTXI. In 1990''s, Na-DMPS was firstapplied to treat the acute poisoning of chlordimeform (CDM) an organoni-trogen insecticide, andbactericide 402, an organosulfur pesticide, and tetramine, a rodenticide. Through thoroughpharmacological and toxicological studies of these non-metallic pesicides, the application ofNa-DMPS as an antidote has been widened, and the development of antidotes against pesticides hasbeen prospected. The application of Na-DMPS as an antidote against non-metallic pesticides is asuccessful example, which shows important theoretical basis and practical value.With the advent of World War II, dimercaptol was first developed in Englandas an effective antidote against arsenical agents. In 1950''s, scientists from the Soviet Uniondeveloped a water-soluble compound, sodium dimercaptopropane sulfonate (Na-DMPS) named as Unithiol(or Unitiol), which was able to chelate heavy metals and metalloids. Unithiol was collected in thePharmacopeia of the Soviet Union. After a lot of efforts of scientists from several countries, thisdrug has been widely used in the treatment of the poisoning of heavy metals and metalloids, as awell-known specific antidote. Considering the importance of sulfhydryl groups in human body, wefirst initiated the possibility of sulfhydryl compounds as antidotes against some non-metaltoxicants. In 1970''s, they screened many sulfhydryl compounds as antidotes against acute poisoningof nereistoxin insecticides (NTXI), and found that dithiol compounds were much better than monothiolcompounds in the treatment for NTXI poisoning. Na-DMPS and sodium dimercapto-succinate (Na-DMS)were among the best antidotes (Fig 1). The accumulation of experimental studies and clinical trialshas confirmed that they were specific effective antidotes against NTXI. In 1990''s, Na-DMPS was firstapplied to treat the acute poisoning of chlordimeform (CDM) an organoni-trogen insecticide, andbactericide 402, an organosulfur pesticide, and tetramine, a rodenticide. Through thoroughpharmacological and toxicological studies of these non-metallic pesicides, the application ofNa-DMPS as an antidote has been widened, and the development of antidotes against pesticides hasbeen prospected. The application of Na-DMPS as an antidote against non-metallic pesticides is asuccessful example, which shows important theoretical basis and practical value.

关 键 词：sodium dimercaptopropane sulfonate ANTIDOTES PESTICIDES nereistoxininsecticides chlordimeform bactericide 402 TETRAMINE poisoning 

分 类 号：R979.3[医药卫生—药品]