高级别星形细胞瘤与脑单发转移瘤的~1H MRS鉴别  

Differential diagnosis between high grade astrocytomas and solitary metastases with^1H MRS

作　　者：刘红军[1] 张云亭[1] 刘松龄[1] 崔世民 刘梅丽 

机构地区：[1]天津医科大学总医院放射科 [2]天津环湖医院,300000

出　　处：《放射学实践》2004年第3期183-186,共4页Radiologic Practice

摘　　要：目的 :探讨活体1 HMRS对高级别星形细胞瘤和单发转移瘤的鉴别诊断价值。方法 :搜集行1 HMRS检查的高级别星形细胞瘤 2 5例 (包括间变型星形细胞瘤 11例 ,胶质母细胞瘤 14例 ) ,单发转移瘤 10例。比较两组肿瘤强化区及肿瘤周围区之间Cho/Cr、NAA/Cr及Lac/Cr值。结果 :2 5例高级别星形细胞瘤与 10例单发转移瘤强化区的Cho/Cr分别为 5 .770 0± 1.82 12及 4.45 0 0± 2 .42 5 0 ,NAA/Cr分别为 0 .9476± 0 .5 0 2 6及 1.185 0± 0 .5 63 7,Lac/Cr分别为 2 .4684± 1.710 5及 3 .2 110± 2 .70 77,两组之间差异均无显著性意义 (P >0 .0 5 )。而肿瘤瘤周区的Cho/Cr分别为 2 .3 3 0 0± 1.2 10 0及1.0 75 0± 0 .2 5 41,差异具有显著性意义 (P <0 .0 0 1) ;NAA/Cr及Lac/Cr之间差异无显著性意义。结论 :应用1Objective:To evaluate the in vivo proton MR spectroscopy in differential diagnosis between high grade astrocytomas and solitary metastases.Methods:25 cases of high grade astrocytomas, including 11 anaplastic astrocytomas and 14 multiform glioblastomas, and 10 solitary metastases were collected. All of them underwent MR spectroscopy. The Cho/Cr、NAA/Cr and Lac/Cr of enhancing region and peritumoral region were compared respectively.Results:The Cho/Cr of 25 high grade astrocytomas and 10 metastases was 5.7700±1.8212 and 4.4500±2.4250,respectively; the NAA/Cr was 0.9476± 0.5026 and 1.1850±0.5637 respectively; the Lac/Cr was 2.4684±1.7105 and 3.2110±2.7077 respectively. But there was no significant difference for all ratios mentioned above between the two groups( P >0.05).The Cho/Cr in peritumoral regions of the two groups was 2.3300±1.2100 and 1.0750±0.2541 respectively, and there was significant difference( P <0.001),but the NAA/Cr and Lac/Cr of the two groups had no significant difference.Conclusion: 1H MRS can be used as a supplementary method to differentiate high grade astrocytomas from solitary metastases, based on the different metabolic levels of peritumoral region.

关 键 词：高级别星形细胞瘤 脑肿瘤 单发转移瘤 鉴别诊断 磁共振波谱分析 

分 类 号：R415.2[医药卫生—临床医学] R739.41