活血化瘀、软坚散结法对子宫内膜异位症自然杀伤细胞活性影响的实验研究  

Experimental study of activity of natural kill cell of Promoting blood circulation to dispel stasis, soften and resolve hard mass on endometriosis.

作　　者：曹立幸[1] 韩冰[2] 李同玺[2] 马平仲[2] 

机构地区：[1]广州中医药大学第二临床医学院,广州510120 [2]天津中医学院第二附属医院,天津300150

出　　处：《河北中医》2004年第4期311-313,共3页Hebei Journal of Traditional Chinese Medicine

摘　　要：目的　观察活血化瘀、软坚散结法 (代表方为妇痛宁颗粒 )对大鼠子宫内膜异位症模型自然杀伤 (NK)细胞活性的影响 ,分析其获效机制。方法　采用手术移植法制备大鼠子宫内膜异位症模型。实验共分 6组 ,即正常对照组、模型对照组和妇痛宁高、中、低剂量组及丹那唑组 ,每组 1 0只 ,观察 6组脾脏NK细胞活性。结果　模型对照组大鼠脾脏NK细胞活性显著低于正常对照组 (P <0 .0 1 )。妇痛宁高、中、低剂量组能够明显提高模型大鼠的脾脏NK细胞活性 ,与模型对照组比较有显著性差异 (P <0 .0 1 ) ,其中中剂量组疗效明显优于高剂量组 (P <0 .0 5 )。结论　子宫内膜异位症大鼠模型存在NK细胞功能异常。活血化瘀、软坚散结法的代表方妇痛宁颗粒冲剂对子宫内膜异位症模型大鼠脾脏NK细胞活性具有显著的调整作用 ,提示可能通过提高NK细胞活性达到治疗子宫内膜异位症的目的。Objective To observe the effect of activity of nature kill cell of Promoting blood circulation to dispel stasis, soften and resolve hard mass on endometriosis, and research the curative mechanism.Methods Maken experimental rat model of endometriosis by surgical implantation. All rats randomly divided into 6 groups. At the end of the experiment, the activity of natural killer (NK) cell in rat's spleen were examined.Results The activity of NK cell in model control group was remarkably lower than that in do nothing control group (P<0.01). But the activities of NK cell in Futongning with moderate dosage, high dosage and low dosage were higher than that in model control group (P<0.01).Conclusion The representative recipe, TCM of Futongning, bases on traditional medical theory of Promoting blood circulation to dispel stasis, soften and resolve hard mass, has a significant effect on regulation of endometriosic model rat's activity of NK cell.

关 键 词：活血化瘀 软坚散结法 子宫内膜异位症 自然杀伤细胞 大鼠 中医药疗法 

分 类 号：R271.917.1[医药卫生—中西医结合]