睾丸支持细胞紧密连接的动力学调控  

The Regulation of Sertoli Cell Tight Junction Dynamics in Spermatogenesis

作　　者：赵勇[1] 张远强[1] 

机构地区：[1]第四军医大学基础医学部组织学与胚胎学教研室,西安710032

出　　处：《细胞生物学杂志》2004年第2期133-138,共6页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(No.39870109);全军医药卫生科研基金(No.01MA183);第四军医大学创新基金(No.CX02A001)资助~~

摘　　要：在睾丸精子发生的过程中,处于细线期和细线前期的精母细胞必须从生精上皮的基底室进入近腔室,这样形态上发育完全的精子才能在精子释放时进入到生精小管的内腔。显然,构成血-睾屏障的支持细胞间紧密连接的开放和关闭受到一系列的信号分子的调节。已经发现的对该过程起调控作用的信号分子包括:转化生长因子β3(TGFβ3)、闭锁蛋白、PKA、PKC等。现就该领域研究的新进展以及可用于研究紧密连接动力学的一些模型进行综述。During spermatogenesis, developing leptotene and preleptotene spermatocytes must translocate from the basal to the adluminal compartment of the seminiferous epithelium so that fully developed spermatids can be released to the tubular lumen at spermiation. Obviously, the opening and closing of the inter-Sertoli tight junctions that constitute the blood-testis barrier are regulated by an array of signal molecules. Transforming growth factor β3 (TGFβ3), occludin, protein kinase A and protein kinase C have been found to be relative to the regulation. This review summarizes some of the recent advances and reviews several models that can be used to study TJ dynamics.

关 键 词：睾丸支持细胞 紧密连接 信号转导 精子发生 信号分子 

分 类 号：R329[医药卫生—人体解剖和组织胚胎学]