从马钱子中选择分离马钱子碱新方法的研究  

STUDY OF NEW METHOD OF SELECTIVE SEPARATION OF BRUCINE IN MAQIANZI

作　　者：郭文生[1] 丁超[1] 宛彤昕[1] Issa Madongo mathurin 李莹[1] 陈颖[1] 

机构地区：[1]辽宁大学化学科学与工程学院,沈阳110036

出　　处：《天然产物研究与开发》2004年第2期97-100,共4页Natural Product Research and Development

基　　金：国家自然科学基金 ( 2 0 3 72 0 3 1) ;沈阳市自然科学基金

摘　　要：本文采用分子模板聚合物技术对中草药马钱子 (Strychnosnux vomicaL .)粗提物中有效成分马钱子碱 (brucine)、士的宁 (strychnine)进行了选择性分离。用丙烯酸为单体 ,TMPTA为交联剂 ,合成对马钱子碱有特异选择性的模板聚合物 (MIP)。选择性分离出粗提物中的马钱子碱 ,纯度可达 99 7% ,同时得到士的宁为主的生物碱 ,纯度为 94 6 %。The technology of the molecular imprinted polymer was adopted to separate selectively brucine and strychnine from strychnos of Chinese herb in this paper. The molecular imprinted polymer(MIP) which has special selectivity to brucine was prepared with monomer of acrylic acid and crosslinker of TMPTA. Brucine was separated selectively from coarse extraction,the purity was up to 99.7%. And the alkaloids mostly containing strychnine was obtained simultaneously,the purity was 94.6%.

关 键 词：模板聚合物 马钱子碱 士的宁 分离 马钱子 丙烯酸 中草药 

分 类 号：R284.2[医药卫生—中药学]