三种鼠尾草注射液对大鼠心肌缺血再灌注损伤的保护作用  

RESEARCH EFFECTS OF SALVIA YUNNANENSIS C.H.WRIGHT, SALVIA PRZERWALSKII MAXIM,SALVIA PRZEWALSKII MAXIM VAR MANDARINORUM STIB DURING ACUTE MYOCARDIAL ISCHEMIA AND REPERFUSION INJURY IN RATS

作　　者：秦剑[1] 李惠兰[1] 张荣平[2] 胡建林[2] 

机构地区：[1]昆明医学院药理教研室,昆明650031 [2]昆明医学院药学院植化室,昆明650031

出　　处：《天然产物研究与开发》2004年第2期143-145,共3页Natural Product Research and Development

基　　金：云南省科委应用基础研究基金 ( 98C0 67M)

摘　　要：本文研究了云南产鼠尾草属药物滇丹参、甘西鼠尾、褐毛甘西鼠尾对急性心肌缺血再灌注损伤的保护作用 ,并与丹参进行对比其疗效的相似性。结扎大鼠冠脉左前降支 ,30分钟后剪断结扎线造成心肌缺血再灌注模型 ,经股静脉给药。测定再灌注 6 0分钟后血清中CK、LDH、SOD、GSH -Px和MDA含量。结果滇丹参、甘西鼠尾、褐毛甘西鼠尾可以显著降低心肌缺血再灌注后血清CK、LDH和MDA含量 ,升高血清SOD和GSH -Px活力 (P <0 0 1,P <0 0 5 ) ,与丹参有相似的抗心肌缺血再灌注损伤作用。Objective:To observe the anti-myocardial ischemia reperfusion injury effects in rats of three herbal drugs: Salvia yunnanensis C.H.Wright,Salvia przerwalskii Maxim and Salvia przewalsk Maxim var mandarinorum stib compared with that of Salvia miltiorhhiza Bunge.Methods:We made the model of myocardia ischemia/reperfusion injury in rats by ligating the LAD for 30 minutes and followed reperfusion 60 minutes.After that, the concentrations of CK, LDH, SOD, GSH-Px and MDA in rats' serum were tested.Results:All the treatment groups in doseage of 4 g/kg can decrease the concentration of CK, LDH and MDA, and can heighten the concentration of SOD and GSH-Px (P<0.01,P<0.05) in serum after acute myocardial ischemia/reperfusion.Conclusion: The three herbal drugs, Salvia yunnanensis C.H.Wright, Salvia przerwalskii Maxim, Salvia przewalskii Maxim var mandarinorum stib have the cardioprotective effects in myocardial ischemia/reperfusion in rat hearts, just as Salvia miltiorhhiza Bunge has.

关 键 词：鼠尾草 注射液 大鼠 心肌缺血 再灌注损伤 滇丹参 甘西鼠尾 褐毛甘西鼠尾 唇形科 

分 类 号：R285[医药卫生—中药学]