105例妊娠期肝内胆汁淤积症临床分析  

Clinical analysis of 105 cases of intrahepatic cholestasis of pregnancy

作　　者：刘大艳[1] 乔福元[1] 刘玉凌[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院妇产科,武汉430030

出　　处：《中国优生与遗传杂志》2004年第2期54-55,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的　探讨妊娠期肝内胆汁淤积症 (ICP)对母儿的不良影响。方法　对 10 5例ICP病人进行回顾性分析。结果　与孕 2 8w以后出现搔痒的患者比较 ,孕 2 8w以前出现搔痒的患者的胆汁酸、转氨酶及胆红素值显著性升高 (P <0 .0 5 ) ,孕妇各种妊娠结局、围生儿结局的发生率及羊水粪染率显著性升高 (P <0 .0 5 )。结论　ICP易引起早产、胎儿宫内窘迫、胎儿突死宫内及母亲产后出血 ,病人发病时间越早 ,围产儿预后越差 ,母亲产后出血发生率及羊水粪染率越高。Objective: To evaluate poor outcomes in the mother and child in intrahepatic cholestasis of pregnancy. Methods: 80 patients with ICP were studied retrospectively. Results: Compared with bile acid, bilirubin and transaminase level of icp patients in the presence of itching after 28 weeks, those of icp patients with itching before 28 significantly increase ( P <0.05), moreover, the incidence of pregnant and fetal outcomes and the rate of meconium staining also significantly increase ( P <0.05). Conclusions: ICP poses significant risk to premature delivery, fetal distress, sudden death and postpartum hemorrhage. The ealier the disease comes on, the worse the fetal prognosis becomes, the higher the rates of postpartum hemorrhage and meconium staining in amniotic fluid rise.

关 键 词：妊娠肝内胆汁淤积症 胆汁酸 羊水 不良结局 

分 类 号：R71425[医药卫生—妇产科学]