新生儿联合免疫效果分析  

The effects of combined immunization in newborn infants

作　　者：杨越波[1] 李小毛[1] 邹玲[1] 沈慧敏[1] 侯红瑛[1] 腾奔琦[1] 

机构地区：[1]中山大学附属第三医院妇产科,广州510620

出　　处：《中国优生与遗传杂志》2004年第2期89-90,117,共3页Chinese Journal of Birth Health & Heredity

基　　金：中山医科大学科研基金;广州市科委科研基金赞助 (编号 :1999-J- 0 0 5- 0 1)

摘　　要：目的　探讨新生儿联合免疫效果的相关因素。方法　于 1999年 12月～ 2 0 0 1年 6月 ,对我院HBsAg阳性孕妇6 2例 ,新生儿出生后 2 4h内予HBIG 10 0IU注射 ,并予HBVac0 ,1,6方案接种 ,新生儿出生后 2 4h内免疫接种前及 12月龄间采静脉血检测血乙肝两对半及HBVDNA定量。结果　HBsAb阳转率为 38.71% ,低反应率为 33.87% ,无反应率为 2 4 .2 0 %。母婴传播阻断保护率为 96 .6 7%。低或无反应组与HBsAb阳转组比较 ,前者出生时宫内感染和 /或HBeAg阳性率高于后者 ,差异有显著性 (P <0 .0 5 )。Objective: To study the related foctors about the effects of combined immunization in newborn infants. Method: From December 1999 to June 2001, 62 newborn infants borned by mother with positive HBsAg receive 10μg of recombinant hepatitis B vaccine and 100IU of HBIG intramuscularly within 24 hours of birth, followed by 10ug of vaccine at 1 months and 6 months of age. Blood specimens of there infants were tested for HBsAg, HBeAg, HBsAb, HBeAb and HBcAb by enzyme linked immunosorbent assay (ELISA),HBV DNA by fluorenscence quantitative polymerase chain reaction (FQ-PCR) in 24 hours after birth before the administration of immune prophylaxis and 12 months of age. Results: After combined immunization, the HBsAb positive rate, low response rate, no response rate and protective rate of infant followed up between 9 and 12 months of age are 38.71%, 33.87%, 24.20% and 96.67%. The intrauterine infection and/or HBeAg positive rate in low or no response group and HBsAb positive group are respectively with statistical significance ( P <0.05). Conclusions: The main cause of low response or no response is contaction with HBV antigen in uterine.

关 键 词：新生儿 联合免疫 相关因素 

分 类 号：R722.1[医药卫生—儿科]