慢性乙型肝炎患者血清HBeAg和HBV DNA水平与肝组织病理关系的探讨  

The relationship between serum HBeAg and HBV DNA levels and grading and staging of liver tissues in patients with chronic hepatitis B

作　　者：姜湘宁[1] 王功遂[1] 尹建军[1] 

机构地区：[1]广东省佛山市顺德第一人民医院内六科,528300

出　　处：《实用肝脏病杂志》2004年第2期86-88,共3页Journal of Practical Hepatology

摘　　要：目的　探讨慢性乙型肝炎患者血清HBeAg、HBVDNA水平与肝组织病理分级分期的关系。方法　应用微粒子荧光免疫分析法 (MEIA)及荧光定量聚合酶链反应法 (PCR)对 167例慢性乙型肝炎患者血清进行HBeAg和HBVDNA定量检测 ,并与同期肝组织活检病理结果对比分析。结果　慢性乙型肝炎患者血清HBeAg定量与病理分级分期有明显相关性 (r =0 .48,p <0 .0 5 ;r =0 .5 3 5 ,p <0 .0 5 ) ,而血清HBVDNA定量与病理分级分期无明显相关性 (r =0 .0 45 ,p =0 .717;r =0 .10 5 ,p =0 .3 83 )。慢性乙型肝炎患者血清HBeAg与HBVDNA定量水平有良好的一致性 (r =0 .5 3 3 ,p <0 .0 5 )。结论　肝组织学炎症分级及纤维化分期与HBeAg定量相关。随着血清HBeAg定量降低 ,肝组织炎症活动加重 ,肝组织纤维化程度升高 ;HBVDNA定量与肝组织炎症及纤维化无明显关系。根据测定慢性乙型肝炎患者血清HBeAg定量的变化 ,可以初步估计肝实质受损情况。结合HBVDNA定量的检测 ,可以为临床判断病情变化、严重程度、HBV前C区变异的初筛及抗病毒治疗方案的选择提供有价值的参考。Objective To investigate the relationship between serum HBeAg and HBV DNA levels and grading and staging of liver tissues in patients with chronic hepatitis B.Methods Serum HBeAg level was assayed by microparticat enzyme immunoassay (MEIA)and serum HBV DNA level by amplisensor quantitative polymerase chain reaction;and the liver biopsy was performed and the grading and staging of the liver were routinely obtained.Results There was a significant relationship between serum HBeAg and grading and staging of liver tissues in patients with chronic hepatitis B,while no obvious correlation was found between serum HBV DNA level and the grading and staging.The serum HBeAg level was consistent with serum HBV DNA level .Conclusion The hepatic activity index and hepatic fibrosis increases as serum HBeAg level decreases;while there is no significant correlation between serum HBV DNA and grading and staging.

关 键 词：慢性乙型肝炎 血清 HBEAG HBVDNA 肝组织病理 

分 类 号：R512.62[医药卫生—内科学]