FoxO转录因子  

Advances in the FoxO Class of Transcription Factors

作　　者：崔旻[1] 赵勇[1] 

机构地区：[1]中国科学院动物研究所生物膜与膜生物工程国家重点实验室移植生物学研究组,北京100080

出　　处：《中国生物工程杂志》2004年第3期40-43,共4页China Biotechnology

摘　　要：FoxO家族是转录调节因子 ,也是INS IGF 1信号通路中的关键分子。FoxO基因在进化上高度保守 ,其氨基酸序列中含有 3个高度保守PKB磷酸化基序。FoxO受PI3K PKB磷酸化级联通路的调节 ,其活性与磷酸化状态直接相关。FoxO对细胞增殖、细胞凋亡等生理过程有重要调节作用 。FoxO class is a subfamily of Forkhead transcription factors,which is an important target of insulin and growth factor signaling.Most members of FoxO group have three highly conserved regions containing a PKB phosphorylation motif.PI3K regulate the activity of FoxO via PKB,which can directly phosphorylate and inactive FoxO.Phosphorylation results in the nuclear exclusion and a reduction in FoxO dependent transcriptional activity.As transcription factor,FoxO plays a critical role in regulation of proliferation,apoptosis,and control of oxidative stress,through activating or repressing the expression of the target gene by multiple mechanisms.The functions of FoxO had also been discussed in regulating apoptosis of lymphocytes and maintaining the immune homeostasis.

关 键 词：FOXO 转录因子 磷酸化 P13K/PKB 免疫调节 凋亡 免疫细胞 

分 类 号：Q75[生物学—分子生物学]