精制甲型肝炎灭活疫苗(YN5株)狨猴试验安全性和免疫原性  

Immunogenicity and Safety of Purified Inactiviated Hepatitis A Vaccine(YN5 Strain)in Common Marmosets

作　　者：马波 胡彩珍[2] 何丽芳 黄果勇 练幼辉 王馨 

机构地区：[1]云南沃森生物技术有限公司,昆明650033 [2]广西壮族自治区疾病预防控制中心,南宁530021

出　　处：《中国生物制品学杂志》2004年第1期36-38,共3页Chinese Journal of Biologicals

基　　金：国家高技术研究发展专项经费资助项目(2 0 0 2AA2Z3 3 13 );云南省科技计划资助项目(2 0 0 1XY0 1)

摘　　要：目的　检测精制甲型肝炎灭活疫苗的安全性和免疫原性。方法　甲型肝炎病毒YN 5株经Vero细胞培养制成精制甲型肝炎灭活疫苗。采用普通狨猴 (commonmarmoset)进行疫苗的安全性、免疫原性和保护力试验。结果　实验疫苗组和对照疫苗组狨猴均有特异抗体产生 ,对甲型肝炎病毒强毒株的攻击亦有保护作用。结论　该疫苗 (YN 5株 )Objective To study the immunogenicity and safety of purified inactivated hepatitis A(HA) vaccine.Methods Prepare purified inactiveted HA vaccine by the culture of YN5 strain in Vero cells and test for immunogenicity and safety in common marmosets,using imported HA vaccine as control.Results Specific HA antibodies were induced in both test and control groups.The vaccine showed protective effect on the marmosets challenged with virulent HA virus strain.Conclusion The HA vaccine prepared with YN5 strain showed good safety and immunagenicity.

关 键 词：甲型肝炎灭活疫苗 安全性 免疫原性 狨猴 保护力 

分 类 号：R512.61[医药卫生—内科学]