DNA序列特征的统计分析  

The Statistical Analysis of the DNA Sequences

作　　者：陈晓燕[1] 鲍伦军[2] 莫金垣[1] 

机构地区：[1]中山大学化学与化学工程学院,广州510275 [2]广州出入境检验检疫局,广州510623

出　　处：《化学通报》2004年第4期284-289,283,共7页Chemistry

基　　金：国家自然科学基金 (2 0 2 0 5 0 0 3);广东省自然科学基金 (990 94 4 )资助项目

摘　　要：介绍了近年来在多种学科领域对 DNA碱基序列的研究中发展起来的定量分析符号序列的方法 ,归纳了将碱基与数字对应起来的规则和进行统计分析的方法 ,并给予一定的评价。 DNA分子包涵了丰富的化学信息和生物信息 ,对于 DNA序列的统计分析显得非常重要。将 DNA序列表达成数字信号通常有从一维到四维 4种不同维数空间的映射方式 ,其相应的统计方法有均方根涨落、熵近似方法、傅立叶变换和小波变换等 ,各种方法从多个角度多个层次来分析揭示了 DNA序列的结构规律。In recent years, scientists adopt various techniques to study the DNA sequences. In this paper, some developing quantitative methods of symbolic sequence analysis for the DNA sequences are introduced. The DNA molecule comprises abundant chemical information and biological information, therefore it is very important to analyze the DNA sequences statistically for the purpose of getting the useful information. We conclude some mapping rules of the bases and the statistical analytical methods. There are several methods to represent the DNA sequences into digital signals, and many statistical methods such as root-mean-square fluctuation, entropy near method, Fourier transform and wavelet transform etc. are used to analyze the DNA sequences.

关 键 词：DNA 定量分析符号序列法 统计分析法 映射方式 均方根涨落 熵近似方法 傅立叶变换 小波变换 碱基序列 

分 类 号：Q75[生物学—分子生物学]