新型K_(ATP)开放剂埃他卡林对氟哌啶醇诱导的大鼠帕金森样症状的影响  

Effects of new ATP-sensitive potassium channel pener iptakalim on Parkinsonian symptoms induced by haloperidol in rats

作　　者：龙燕[1] 杨勇[1] 丁建花[1] 胡刚[1] 

机构地区：[1]南京医科大学药理学与神经生物学系

出　　处：《中国临床药理学与治疗学》2004年第4期378-381,共4页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：国家创新药物基础研究重大项目 (№ 9690 10 10 1);国家自然科学基金资助项目 (№ 3 9970 846)

摘　　要：目的 :研究ATP敏感性钾通道 (ATP sensitivepotassiumchannels ,KATP)开放剂埃他卡林 (iptakalim ,Ipt)对由氟哌啶醇 (haloperidol)诱导产生的大鼠帕金森样症状的影响。方法 :应用氟哌啶醇诱导大鼠帕金森样症状 ,以左旋多巴 (levodopa ,L DOPA)为阳性对照 ,观察不同剂量Ipt对大鼠运动潜伏时间、行走时间以及直立和梳洗次数的影响。结果 :Ipt能显著改善氟哌啶醇引起的大鼠自发性活动减少 ;能缓解氟哌啶醇引起的大鼠全身僵硬 ,并且随剂量的增加 ,Ipt的作用逐渐增强。结论 :KATP通道开放剂Ipt能够改善氟哌啶醇引起的大鼠帕金森样症状 ,是一个极富治疗潜力的先导化合物。AIM : To investigate the effects of the new K ATP channel opener, iptakalim (Ipt), on the Parkinsonian symptoms induced by haloperidol in rats. METHODS : Using L -DOPA as the positive drug, the influences of Ipt on latency time, walking time, rearing and grooming of the parkinsonian-like rats induced by haloperidol were observed. RESULTS : Ipt ameliorated hypolocomotion and assuaged catalepsy induced by haloperidol in rats. Moreover, the effects of Ipt ( 0.5 mg·kg -1) were better than those of L -DOPA (100 mg·kg -1). CONCLUSION : Opening of K ATP channels may play a key role in improving Parkinsonian symptoms induced by haloperidol in rats.

关 键 词：ATP敏感性钾通道 开放剂 埃他卡林 氟哌啶醇 帕金森样症状 

分 类 号：R965.1[医药卫生—药理学]