卡马西平治疗74例儿童癫痫的血药浓度监测  

Monitoring Serum Carbamazepine Concentrations in74Child Epilepsy Patients

作　　者：任洁雯[1] 陈怡禄[1] 杨彤[1] 潘丽雯[1] 

机构地区：[1]广州市儿童医院,广州市510120

出　　处：《中国药房》2004年第5期291-292,共2页China Pharmacy

摘　　要：目的 :指导临床合理应用卡马西平。方法 :采用荧光偏振免疫法对74例服用卡马西平10～20mg/(kg·d)的癫痫患儿进行血药浓度监测。结果 :有效控制发作的血药浓度为 (4 16±2 07) μg/ml,其中在经典有效血药浓度范围 (4～12μg/ml)内占61 4 %(27/44) ;疗效不足的血药浓度为 (3 80±1 18) μg/ml,其中在经典有效范围内占44 4 % (4/9) ;发作无效的血药浓度为 (4 90±1 78) μg/ml,其中在经典有效范围内占65 0 % (13/20) ;不良反应发生率为1 4 % (1/74)。结论 :癫痫患儿应用卡马西平10～20mg/(kg·d)是安全有效的。OBJECTIVE:To guide the rational use of carbamazepineCBZ.METHODS:The serum concentrations of CBZ were determined by fluorescence polarization immunoassayFPIAin74child patients with epilepsy.RESULTS:The effective serum concentrations of CBZ was4.16±2.07μg/ml.Those within classical effective concentration range of CBZCBZ-CEˉCR4～12μg/mlaccounted for61.4%27/44;The insufficiently effective serum concentration of CBZ was3.80±1.18μg/ml.Those within CBZ-CECR accounted for44.4%4/9;The ineffective serum concentration of CBZ was4.90±1.78μg/ml.Those within CBZ-CECR accounted for65.0%13/20;The rate of adverse reactions was1.4%1/74.CONCLUSION:The daily dosages of CBZ10～20mg/kg·dis safe and effective for child epilepsy.

关 键 词：卡马西平 血药浓度监测 荧光偏振免疫法 

分 类 号：R971[医药卫生—药品]