微生态制剂治疗肝源性肠道菌群失调与保肝作用  

Lacteol fort as an adjunctive treatment for chronic hepatitis and approaching the mechanism of microecological preparation(deceased bacteria) treatment

作　　者：张纪伟[1] 

机构地区：[1]上海第二医科大学附属新华医院,上海200092

出　　处：《中国微生态学杂志》2004年第1期34-35,共2页Chinese Journal of Microecology

摘　　要：目的 :观察采用常规保肝治疗及或加服乐托尔或加服培菲康来治疗慢性肝病疗效。方法 :慢迁肝 4 1例及慢活肝 37例 ,各随机分成三组 :A组 :常规治疗 +乐托尔胶囊 ,2粒 /次 ,2次 /d ;B组 :常规治疗 +培菲康胶囊 ,3粒 /次 ,3次 /d ;C组 :常规治疗 :益肝灵 +Vit.C +Vit.BCo ,各 2片 /次 ,3次 /d ,三组疗程均为2个月。结果 :75例完成治疗及复查 ,失访 3例。腹胀、腹泻、肝区不适消失率及ALT、内毒素试验复常率二项三组相比有显著意义 (P <0 0 1)。乏力、SB复常率在慢活肝中三组相比有显著意义 (P <0 0 1)。总有效率 :慢迁肝三组分别为 83 3%、6 9 2 %、35 7% ;慢活肝三组分别为 :6 3 7%、6 1 5 %、33 3% ,三组相比有显著意义 (P <0 0 1)。结论 :常规保肝治疗加服微生态制剂 ,不论是死菌及其代谢产物或活菌制剂均有肯定的价值 。Objective:To observe and compare the efficacies of treating chronic liver diseases with conventional liver protecting treatment and that in combination with Lacteol for or Pei Fei Kang.Method:Forty one patients with chronic persistent hepatitis and 37 patients with chronic active hepatitis were allocated randomly into 3 groups:patients of group A received conventional treatment+Lacteol fort 2 capsules bid;patients in group B received conventional treatment+Pei Fei Kang 3 capsules tid and patients in group C received conventional treatment including Silymarin+Vit.C+Vit.B Co.,2 tablets each tid,but the course of therapy was two month in all 3 groups.Results:Seventy five of the patients completed the treatment and follow up study.Three patients were lost in follw up.Significant differeces( P <0 01)existed between 3 groups in the rates of disapperance of abdominal distension,diarrhea and discomfort over hepatic area and rates of normalization of ALT and limulus lysate test.Sinificant differences( P <0 01) also existed between 3 groups of patients with chronic active hepatitis in normalization of asthenia and serum bilirubin.The global effective rates in 3 groups of chronic persistent hepatitis were 83 3%,69 2%and 35 7% respectively;and in 3 groups of chronic active hepatititis were 63 7%,61 5% and 33 3% respectively.There existed significant differences between 3 groups ( P <0 01).Conclusions:Microecological preparations,no matter it is killed bacterial preparation and bacterial metabolic productrs or viable bacterial preparation,in combination with conventional treatment are definitely beneficial to the patients with chronic hepatic diseases.The killed bacterial preparations possess the advantages that the viable bacterial prepparations do not offer.

关 键 词：微生态制剂 治疗 慢性肝炎 肠道 菌群失调 保肝作用 乐托尔 

分 类 号：R945[医药卫生—微生物与生化药学] R575[医药卫生—药剂学]