番茄汁对D-半乳糖衰老模型大鼠海马神经元的抗衰老作用  

Effect of tomato juice against aging of hippocampal neurons in D-galactose induced aging rat model

作　　者：范晓岚[1] 糜漫天[1] 崔力[2] 杨军[3] 尚立中 王英 

机构地区：[1]解放军第三军医大学营养与食品卫生教研室,重庆市400038 [2]吉林大学基础医学院电镜室,吉林省长春市130021 [3]中国医科大学营养与食品卫生教研室,辽宁省沈阳市110001 [4]总装备部卫生技术训练大队,辽宁省沈阳市110032

出　　处：《中国临床康复》2004年第13期2466-2467,共2页Chinese Journal of Clinical Rehabilitation

摘　　要：目的:探讨番茄汁对衰老模型大鼠海马神经元的抗衰老作用。方法:采用随机数字表将30只Wistar大鼠随机分成3组,建立D-半乳糖亚急性衰老模型,采用生化、光镜和电镜等方法,观察番茄汁对衰老大鼠海马神经元的影响。结果:番茄汁组大鼠大脑丙二醛含量犤(3.41±0.36)μmol/g犦,与乳糖组犤(4.01±0.27)μmol/g犦相比显著降低(P<0.05),超氧化物歧化酶(SOD)活性犤(25.06±1.86)NU/mg犦与D-半乳糖组犤(20.63±2.52)NU/mg犦相比明显增高(P<0.01);海马神经元形态结构衰老征象明显减轻。结论:番茄汁可延缓海马神经元的衰老进程,具有一定的抗衰老作用。AIM:To discuss the role of tomato juice in preventing hippocampal neurons agai nst aging in D-galactose induced aging rats. METHODS:According to random number table,30 Wistar rats were divided into thre e groups at random.D-galatcose induced subacute aging models were established i n rats.Biochemistry,light microscope and electron microscope were used to observ e the effect of tomato juice on hippocampal neurons of aging rats. RESULTS:Compa red with the D-galatcose group[(4.01 ±0.27) μmol/g,(20.63±2.52)NU/mg],the le vels of malondialdehyde was significantly decreased in the tomato juice group[(3 .41±0.36) μmol/g](P< 0.05),however,the activity of superoxide dismutase was si gnificantly increased in the tomato juice group[(25.06±1.86) NU/mg](P< 0.01).Th e aging symptoms of morphological structure of hippocampal neurons were remarkab ly relieved. CONCLUSION:The tomato juice can delay the aging process of hippocampal neurons ,and have a anti-aging role to a certain extent.

关 键 词：番茄汁 D-半乳糖 衰老 动物模型 大鼠 海马神经元 抗衰老 

分 类 号：R339.38[医药卫生—人体生理学] R-33[医药卫生—基础医学]