灯盏花素注射液对缺血性视神经病变患者血流动力学的影响(英文)  

Influence of Breviscapine injection on hemodynamics in ischemic optic neuropath

作　　者：廖海兰[1] 阎亦农[2] 徐晓红[3] 

机构地区：[1]广东医学院附属医院眼科,广东省湛江市524001 [2]汕头大学/香港中文大学联合汕头国际眼科中心,广东省汕头市515041 [3]广东医学院附属医院超声科,广东省湛江市524001

出　　处：《中国临床康复》2004年第13期2594-2595,共2页Chinese Journal of Clinical Rehabilitation

摘　　要：背景:眼前部缺血性视神经病变(anteriorischemicopticneuropathy,AION)是由于视神经神经局部供血不足,引起视神经局部缺血缺氧,而视力下降、视野缺损的疾病,目前,AION确切的发病机理尚未证实。目的:观察灯盏花素注射液治疗眼前部缺血性视神经病变(AION)后患者血流动力学的变化。设计:以诊断为依据的病例对照研究。地点和对象:AION患者36例,为广东医学院附属医院1999-01/2002-02份住院患者,男16例,女20例,年龄最小40岁,最大76岁,平均55.4岁。干预:给予灯盏花素注射液50mg加入250mL生理盐水中静脉点滴,1次/d,每个疗程10d。主要观察指标:应用彩色超声多普勒技术,检测36例(36只眼)AION患者应用灯盏花素注射液治疗前后眼动脉、睫状后短动脉、视网膜中央动脉血流动力的改变,并与对侧健眼进行比较。结果:应用灯盏花素治疗后,患者眼动脉收缩期血流速度舒张末期血流速度和阻力指数分别为(32.74±3.56)cm/s,(17.12±2.15)cm/s,0.63±0.03,睫状后短动脉收缩期血流速度舒张末期血流速度和阻力指数分别为(12.35±1.60)cm/s,(5.96±0.86)cm/s,0.59±0.03,视网膜中央动脉收缩期血流速度舒张末期血流速度和阻力指数分别为(15.41±1.62)cm/s,(5.71±0.830)cm/s,0.64±0.02,治疗后眼动脉、睫状后短动脉、视网膜中央动脉收?BACKGROUND:Anterior ischemic optic neuropathy(AION) is a kind of disease with eyesight declined and defect of visual field caused by deficiency of local blood supply inducing local ischemia of the optic nerve. The pathological mechanism o f AION still remains unclear. OBJECTIVE:To observe the changes of AION patients' hemodynamics after Brevisca pine injection. DESIGN:Case-control study based on diagnosis. SETTING and PARTICIPANTS:Thirty-six AION patients,who were the inpatients of Hospital Attached to Guangdong School of Medicine from January 1999 to February 2002,were composed of 16 males and 20 females,with age from 40 to 76,55.4 years old on average. INTERVENTION:Mix solution of 50 mg Breviscapine and 250 mL normal sodium was i njected into vein,once a day, and 10 days as a course. MAIN OUTCOME MEASURES:Multi-color Ultrasonic Doppler technique was used befor e and after injection of Breviscapine to detect hemodynamical changes of ophthal mic artery,short posterior ciliary artery and central retinal artery in 36 eyes of AION patients.The health eyes were treated as controls. RESULT:After treatment with Breviscapine injection,the blood flow velocity dur ing systole and relaxing period and the resistant index of ophthalmic artery wer e(32.74±3.56)cm/s,(17.12±2.15) cm/s,0.63±0.03 respectively.Those of the sho rt posterior ciliary artery were(12.35±1.60) cm/s,(5.96±0.86) cm/s,0.59±0.03, and(15.41±1.62) cm/s,(5.71±0.830) cm/s and 0.64±0.02 for central retinal arte ry.That was to say the blood flow velocity during systole and relaxed period of these arteries increased obviously, while the drag index declined clearly.Compar ed with the data get before treatment[(8.53±2.15) cm/s,(2.98±0.94) cm/s,0.71± 0.03],the difference was significant(P< 0.01). CONCLUSIONS:AION hemodynamiccal parameters can be obviously improved by the in jection of Breviscapine without obvious side effects.

关 键 词：灯盏花素注射液 血流动力学 眼前部缺血 视神经病变 药物治疗 

分 类 号：R276.746[医药卫生—中医五官科学] R318.01[医药卫生—中医学]