邻基参与反应历程探讨  

Discussion of Neighboring Group Participation in Reaction Course

作　　者：龙德清[1] 黄明权[1] 

机构地区：[1]郧阳师范高等专科学校化学系,湖北丹江口442700

出　　处：《郧阳师范高等专科学校学报》2003年第6期27-30,共4页Journal of Yunyang Teachers College

摘　　要：邻基参与反应的历程主要有三类 ,即n—参与历程、π—参与历程和σ—参与历程 ;分为二步 :( 1)反应物的邻基从反面进攻α—碳原子 ,形成中间体 ,构型转化一次 ,为分子内的SN2反应 ;( 2 )外部的亲核试剂Nu—从邻基的反面进攻中间体 ,构型又转化一次 ,再发生一次分子内SN2反应 ,其结果是 :该类反应总的来说属于SN1反应历程 。There are three kinds of neighboring group participation in reaction course, which is n—participation course and o—participation course. They are divided into two steps: neighboring group of response matter attacks α—carbon atom from reverse side, takes shape into intermediate, and the type transforms once, which is S_(N)2 reaction in molecule; outside nucleophile Nu^(—) attacks the intermediate from reverse side of neighboring group, the type transforms once again, and S_(N)2 reaction in molecule happens once again. The result is that, this kind of reaction generally belongs to S_(N)1 reaction course, and the type of production keeps intact.

关 键 词：邻基参与 中间体 亲核取代反应 反应历程 

分 类 号：O621[理学—有机化学]