树突状细胞、郎格罕氏细胞在声带息肉中浸润的意义  

The infiltration of dendritic cells ,Langerhan′s cells in polyp of vocal cord

作　　者：田广永[1] 张国民[1] 孙滨滨[1] 董明敏[2] 

机构地区：[1]河南大学淮河医院,河南开封475000 [2]郑州大学第一附属医院

出　　处：《山东大学基础医学院学报》2004年第2期102-104,共3页Journal of Preclinical Medicine College of Shandong Medical University

摘　　要：目的 :探讨树突状细胞 (dendriticcells ,DC)、郎格罕氏细胞 (Langerhan′scells ,LC)在声带息肉浸润中的意义。方法 :选择息肉样变性 30例和增生型息肉 30例石蜡标本重新制备 ,用免疫组化技术SABC法作S- 10 0单克隆抗体染色和HE染色 ,进行定量检测。结果 :息肉样变型组息肉上皮内的DC/LC浸润密度平均为 1.4 0± 1.0 3个 /16HP ,间质内的DC浸润密度平均为 11.10± 4 .0 7个 /16HP。增生型组的息肉上皮内的DC浸润密度平均为 0 .73± 1.0 8个 / 16HP ,间质内的DC浸润密度平均为 3.13± 2 .78个 / 16HP。两组息肉内DC/LC浸润密度差异有显著性 (P <0 .0 1)。结论 :声带息肉中DC/LC浸润密度与声带息肉的预后及临床分型有关。Objective:To investigate the significance of dendritic cells(DC)and Langerhan′s cells(LC) infiltrating in polyps of vocal cord.Method:The DCs and LCs were observed by immunohistochemical method with the use of anti-S-100 protein antibody in 30 cases of polyp of vocal cord with hyperplasia and 30 cases of it without hyperplasia.Result:The difference of the infiltration of DC/LC in the 2 groups was statistically significant( P<0.05) in the epithelium, so in the interstitium too(P<0.01).Conclussion: It is possible that the highly infiltrating of DC/LC is one of the causes in development of polyps of vocal card. The polyp of vocal cord with hyperplasia is possible to become into laryngeal carcinoma.

关 键 词：树突状细胞 郎格罕氏细胞 声带息肉 DC 临床资料 

分 类 号：R767.4[医药卫生—耳鼻咽喉科]