吲哚美辛联合干扰素治疗慢性乙型肝炎患者的疗效及其机理初探  

Effect of indomethacin combined with interferon in treating chronic hepatitis B

作　　者：李莹[1] 李文凡[1] 

机构地区：[1]兰州医学院第一附属医院感染科,兰州730000

出　　处：《中国综合临床》2004年第4期326-328,共3页Clinical Medicine of China

摘　　要：目的　探讨吲哚美辛 (INDO)联合干扰素治疗慢性乙型肝炎的疗效及其对血清细胞因子分泌模式的调节作用。方法　 78例慢性乙肝患者随机分为两组 ,分别以干扰素 α(IFN α)和IFN α +INDO治疗 6个月。观察治疗前后血清IFN γ、IL 4及IFN γ/IL 4比值水平的变化。结果　慢性乙肝患者血清IFN γ及IFN γ/IL 4均明显低于正常对照组 ,IL 4明显高于正常对照组 ,治疗后所有患者均有IFN γ、IFN γ/IL 4的升高及IL 4的降低 ,且IFN +INDO组较IFN组变化趋势更加明显 (P <0 .0 5 ) ;IFN +INDO组临床有效率明显好于IFN组 (P <0 .0 5 )。结论　吲哚美辛在慢性乙肝治疗过程中能提高IFN α抗病毒能力 ,其机制似与调节T应答模式向Th1/Tc1应答转变有关。Objective To investigate the effect of indomethacin(INDO) combined with interferon in treating chronic hepatitis B and its regulation to serum cytokine subsets.Methods 78 cases of chronic hepatitis B were randomly divided into two groups,who were treated with interferon-α and interferon-α + INDO,respectively,for 6 months.Observation was made of serum IFN-γ,IL-4 and IFN/IL-4 levels.Results IFN-γ and IFN-γ/IL-4 were remarkably lower but IL-4 was remarkably higher in chronic hepatitis B patients than in normal control group.After treatment,IFN-γ and IFN-γ/IL-4 were elevated and IL-4 was lowered in all patients,which was more obvious in the IFN+INDO group rather than in IFN group(P<0.05).The effective rate of IFN+INDO group was significantly higher than that of IFN group(P<0.05).Conclusion INDO can enhance the antivirus effect of interferon-α in hepatits B virus chronic active hepatitis,with mechanism of transforming T cell response to Th1/Tc1 model.

关 键 词：肝炎 乙型 吲哚美辛 干扰素-Α 

分 类 号：R512.62[医药卫生—内科学]