肾血康对肾性贫血大鼠外周血象与红细胞脆性及EPO含量的影响  

The Effect of Shenxuekang on the Peripheral Blood Counts Erythrocyte Fragility and EPO Level in Renal Anemia Rats

作　　者：汪军[1] 郑佳新[1] 张春戬[1] 

机构地区：[1]黑龙江省中医研究院,哈尔滨150036

出　　处：《中国中西医结合肾病杂志》2004年第4期195-196,共2页Chinese Journal of Integrated Traditional and Western Nephrology

基　　金：黑龙江省自然科学基金资助项目 (No .D0 1-3 3 )

摘　　要：目的 :探讨肾血康治疗肾性贫血大鼠的药理、药效。方法 :将SD大鼠随机分为空白组、模型组及中药组 ,以中药肾血康对腺嘌呤所致慢性肾衰竭大鼠进行治疗 ,并比较大鼠治疗前后的外周血象、EPO含量、红细胞脆性等各项指标。结果 :肾血康能降低肾衰竭大鼠血中Scr及BUN ,降低红细胞脆性 ,而升高其血中Hb、RBC、HCT、EPO水平。结论 :肾血康能有效改善腺嘌呤所致慢性肾衰竭大鼠的贫血症状 ,防止肾小球硬化 。Objective:To explore the pharmacology and pharmacodynamics of Shenxuekang on peripheral blood counts in renal anemia rats.Methods:SD rats were randomly divided into three groups:control group, therapy group and model group.CRF was induced adenine in rats. Rats were treated with Shenxuekang and experimental targets were compared before and after treatment.Results:Shenxuekang decreased Scr, Bun and erythrocyte fragility while increased the level of Hb, RBC, HCT and EPO.Conclusion:Shanxuekang can effectively improve renal anemia induced by adenine, prevent glomerulosclerosis and delay the deterioration of renal function.

关 键 词：肾血康 肾性贫血 大鼠 外周血象 红细胞脆性 EPO 肾小球硬化 

分 类 号：R285.5[医药卫生—中药学]