黄芩对大鼠胚胎致畸作用的观察  

Observations of Teratogenic Effects of Scutellaria Baicalensis Georgi on Embryos of Rats

作　　者：杨丽萍[1] 杨幼明[1] 杨钧[1] 周文江[1] 

机构地区：[1]复旦大学实验动物科学部,上海市200032

出　　处：《中国比较医学杂志》2003年第3期155-158,共4页Chinese Journal of Comparative Medicine

摘　　要：目的　了解黄芩对SD大鼠胚胎的影响。方法　妊娠的雌性SD大鼠随机分成阴、阳性组及高、中、低剂量组 ,每组 15只 ,称重和编号。孕鼠于妊娠 7～ 16d灌胃染毒 ,2 0d处死 ,分析胚胎发育指标与胎仔发育指标 ,检查有无外观畸形和骨骼畸形。结果　与阴性对照组比较 ,黄芩各实验组孕鼠体重增长未见显著减慢 ,活产仔数未见显著减少 ,死胎率和吸收胎率未见显著增加 ,胎仔平均体重、体长、尾长发育指标未见显著减缓 ,外观畸形和骨骼畸形未见显著增加。结论　在本实验剂量与条件下黄芩无母体毒性、胚胎毒性。Objective To study teratogenic effects of Scutellaria baicalensis Georgi on embryos of SD rats. Method Gravid femals SD rats were randomly divided into five groups, then weighed and tagged. They were administered from 7 through 16 days of their gestation. The rats were weighed and killed on the 20th day of the gestation, embryonic developmental parameters and fetal developmental parameters were analysed, external and skeletal anomalies were examined. Results No significant differences were observed between the Scutellaria baicalensis Georgi dosage groups and the negative control group in body weight gain in pregnant rats. And there were no reduction of number of survivals at birth, no increment of incidence of stillbirth, no decrement of mean body weight, body length and tail length, no retardation of skeletal development, no increment of incidence of external and skeletal anomalies in the fetuses of experimental groups. Conclusion Scutellaria baicalensis Georgi has no maternal toxicity, embryonic and developmental toxicity and teratogenicity under the experimental conditions.

关 键 词：黄芩 大鼠 胚胎 致畸作用 中药 内脏发育 

分 类 号：R285.5[医药卫生—中药学] R-332[医药卫生—中医学]