The effect of famotidine on gastroesophageal and duodeno-gastro-esophageal refluxes in critically ill Patients  

作　　者：YingXin NingDai LanZhao Jian-GuoWang Jian-MingSi 

机构地区：[1]DepartmentofGastroenterology,SirRunRunShawHospital,Hangzhou310016,ZhejiangProvince,China [2]ZhejiangUniversity,medicalcollege,Hangzhou310031,ZhejiangProvince,China

出　　处：《World Journal of Gastroenterology》2003年第2期356-358,共3页世界胃肠病学杂志（英文版）

摘　　要：AIM: To investigate t he effect of famotidine ongastroesophageal reflux (GER) and duodeno-gastro-esophageal reflux(DGER) and to explore it's possiblemechanisms. To identify the relevant factors of the reflux.METHODS: Ninteen critically iii patients were consecutivelyenrolled in the study. Dynamic 24 hours monitoring of GERand DGER before and after administration of famotidine wasperformed. The parameters of gastric residual volume,multiple organ disorder syndrome (NODS) score, acutephysiology and chronic health evaluation Ⅱ (APACHE Ⅱ) scoreand PEEP were recorded. Paired ttest; Wilcoxon signedranks test and Univariate analysis with Spearman's rankcorrelation were applied to analyse the data.RESULTS: Statistical significance of longest acid reflux,reflux time of pH＜4 and fraction time of acid reflux wasobserved in ten critically ill patients before and afteradministration. Pvalue is 0.037, 0.005, 0.005 respectively.Significance change of all bile reflux parameters wasobserved before and after administration. Pvalue is 0.007,0.024, 0.005, 0.007, 0.005. GER has positive correlationwith APACHE Ⅱ score and gastric residual volume withcorrelation coefficient of 0.720, 0.932 respectively.CONCLUSION: GER and DGER are much improved afterthe administration of famotidine. GER is correlated withAPACHE Ⅱ score and gastric residual volume.AIM:To investigate the effect of famotidine on gastroesophageal reflux(GER)and duodeno-gastro- esophageal reflux(DGER)and to explore it's possible mechanisms.To identify the relevant factors of the reflux. METHODS:Ninteen critically ill patients were consecutively enrolled in the study.Dynamic 24 hours monitoring of GER and DGER before and after administration of famotidine was performed.The parameters of gastric residual volume, multiPle organ disorder syndrome(MODS)score,acute physiology and chronic health evaluation Ⅱ(APACHE Ⅱ)score and PEEP were recorded.Paired ttest;Wilcoxon signed ranks test and Univariate analysis with Spearman's rank correlation were applied to analyse the data. RESULTS:Statistical significance of longest acid reflux, reflux time of pH<4 and fraction time of acid reflux was observed in ten critically ill patients before and after administration.Pvalue is 0.037,0.005,0.005 respectively. Significance change of all bile reflux parameters was observed before and after administration.Pvalue is 0.007, 0.024,0.005,0.007,0.005.GER has positive correlation with APACHE Ⅱ score and gastric residual volume with correlation coefficient of 0.720,0.932 respectively. CONCLUSION:GER and DGER are much improved after the administration of famotidine.GER is correlated with APACHE Ⅱ score and gastric residual volume.

关 键 词：法莫替丁 胃食管返流病 药理作用 临床特点 X线检查 

分 类 号：R975[医药卫生—药品] R57[医药卫生—药学]