中国南海海绵Cinachyrella australiensis化学成分研究  

Chemical constituents from chinese marine sponge Cinachyrella australiensis

作　　者：李莉娅[1] 邓志威[2] 李军[1] 付宏征[1] 林文翰[1] 

机构地区：[1]北京大学天然药物及仿生药物国家重点实验室,北京100083 [2]北京师范大学分析测试中心

出　　处：《北京大学学报（医学版）》2004年第1期12-17,共6页Journal of Peking University:Health Sciences

基　　金：国家高技术研究发展计划专项经费 ( 2 0 0 1AA62 40 3 0 ;2 0 0 2AA2 170 81);国家自然科学基金 ( 3 0 17110 6;40 1760 3 8)资助~~

摘　　要：目的 :研究中国南海海绵Cinachyrellaaustraliensis的化学成分。方法 :用多种色谱技术进行分离纯化 ,根据理化性质和波谱数据进行结构鉴定。结果 :从中国南海海绵C .australiensis中分离得到 1 9个化合物 ,分别为2 甲氧基 6 ,1 2 ,1 5 三烯 8 炔 十八酸 (1 ) ,邻苯二甲酸二正丁基酯 (2 ) ,邻苯二甲酸二 (2 乙基 ) 己基酯 (3) ,( )(3S) 1 ,2 ,3,4 四氢 β 咔啉 3 羧酸 (4 ) ,L 色氨酸 (5 ) ,对羟基苯甲醛 (6 ) ,对羟基苯乙醇 (7) ,对羟基苯丙醇 (8) ,胆甾 4 烯 3 醇 (9) ,2 甲基 6 氨基嘌呤脱氧核苷 (1 0 ) ,6 氨基嘌呤脱氧核苷 (1 1 ) ,6 氨基嘌呤核苷 (1 2 ) ,尿嘧啶 (1 3) ,胸腺嘧啶 (1 4 ) ,胸腺嘧啶脱氧核苷 (1 5 ) ,尿嘧啶脱氧核苷 (1 6 ) ,乙基 α 脱氧核糖苷 (1 7) ,异光黄素 (1 8) ,zarzissine(1 9)。结论 :1和 1 8为新化合物 ,化合物 2～ 1 7,1Objective: To investigate the secondary metabolites from Chinese marine Sponge Cinachyrella australiensis. Methods: Column chromatography techniques including HPLC were used for the separation and purification of the compounds, and extensive spectral analyses including various 2D NMR spectra were employed for structure elucidation. Results: Nineteen compounds were obtained ,including 2 methyoxy 6,12,15 trien 8 yne octadecanoic acid(1), 2 benzenedicarboxylic acid dibutyl ester(2), 1,2 benzenedicarboxylic acid bis(2 ethylhexyl)ester(3), ( ) (3S) 1,2,3,4 tetrahydro β carboline 3 carboxylic acid(4), L Tryptophan (5), p hydroxylbenzaldehyde (6), p hydroxyl benzylethanol(7), p hydroxyl benzyl propanol(8), cholesta 4 en 3 ol(9), 2 methyl 6 amino 9 (2 deoxy β D ribofuranosyl purine(10), 2' Deoxyadenosine (11), 6 amino 9 β D ribofuranosyl 9H purine (12),uracil(13), thymine(14), thymidine(15), 1 (2 deoxy β D Ribofuranosyl)uracil(16), 1 ethyl α (2 deoxy) β D ribofuranos(17),isolumichrome(18),and zarzissine(19).Conclusion:Compounds 1 and 18 are new natural products,and compounds 2 to 17 as well as 19 are isolated from this species for the first time.

关 键 词：海洋药 海绵 化学成分 色谱技术 结构鉴定 纯化 

分 类 号：R282.77[医药卫生—中药学]