硫化氢——心血管功能调节的新型气体信号分子  

Hydrogen sulfide: a novel cardiovascular functional regulatory gas factor

作　　者：耿彬[1] 闫辉[2] 钟光珍[3] 张春雨[2] 陈晓波[2] 蒋宏峰[1] 唐朝枢[1] 杜军保[2] 

机构地区：[1]北京大学基础医学院生理学系 [2]北京大学第一医院儿科,北京100034 [3]北京大学第三医院心内科

出　　处：《北京大学学报（医学版）》2004年第1期106-106,共1页Journal of Peking University:Health Sciences

基　　金：国家重点基础研究发展规划项目基金 (G2 0 0 0 0 5 690 5 );国家自然科学基金 ( 3 0 2 713 73 )资助~~

摘　　要：Hydrogen sulfide (H 2S) may be endogenously produced by cystathionine β lyase (CBS) and cystathionine γ lyase (CSE) as a cardiovascular physiological functional factor. On the hypoxic pulmonary hypertension (HPH) animal model, the plasma H 2S concentration, the gene expression and the activity (CSE) were decreased in lung tissues In L -NAME induced hypertension and spontaneous hypertension rats (SHR) models, the plasma H 2S concentration, vascular CSE activity and mRNA expression were obviously decreased. When H 2S was exogenously supplied, systolic pressure obviously decrease. These studies suggested that CSE/H 2S pathway participated in the pathophysiological development of hypertension. The endogenous level of H 2S produced by some arterial tissues increased in both septic and endotoxic shock rats. The level of H 2S highly correlated with the endogenous level of NO These results suggest that H 2S may be a novel cardiovascular functional regulator.Hydrogen sulfide (H 2S) may be endogenously produced by cystathionine β lyase (CBS) and cystathionine γ lyase (CSE) as a cardiovascular physiological functional factor. On the hypoxic pulmonary hypertension (HPH) animal model, the plasma H 2S concentration, the gene expression and the activity (CSE) were decreased in lung tissues In L -NAME induced hypertension and spontaneous hypertension rats (SHR) models, the plasma H 2S concentration, vascular CSE activity and mRNA expression were obviously decreased. When H 2S was exogenously supplied, systolic pressure obviously decrease. These studies suggested that CSE/H 2S pathway participated in the pathophysiological development of hypertension. The endogenous level of H 2S produced by some arterial tissues increased in both septic and endotoxic shock rats. The level of H 2S highly correlated with the endogenous level of NO These results suggest that H 2S may be a novel cardiovascular functional regulator.

关 键 词：硫化氢 心血管功能 气体信号分子 内源性一氧化碳 内源性一氧化氮 

分 类 号：R331.3[医药卫生—人体生理学]