肝细胞内Ca^(2+)振荡对磷酸化-去磷酸化循环过程的动力学研究  

Kinetics of Process of Phosphorylation-dephosphorylation Cycle in Hepatocytes by Ca^(2+) Oscillations

作　　者：陈昌胜[1] 曾仁端[1] 

机构地区：[1]华中科技大学同济医学院基础医学院数理计算中心,武汉430030

出　　处：《华中科技大学学报（医学版）》2004年第2期215-218,共4页Acta Medicinae Universitatis Scientiae et Technologiae Huazhong

摘　　要：目的　从理论上阐述了Ca2 + 振荡对肝细胞中糖原降解的磷酸化 去磷酸化循环过程的调控效应。方法　应用Ca2 + 振荡模型观察Ca2 + 振荡对肝细胞中糖原降解的磷酸化循环过程的调控。结果　Ca2 + 振荡可以增强细胞对激素反应的潜力。肝细胞中的磷酸化 去磷酸化动力学过程 ,在Ca2 + 振荡的调控下 ,其糖原磷酸化酶的浓度呈现同频、同步振荡。结论　Ca2 + 振荡将会提高细胞中信息的传递效率和特异性。Objective To investigate theoretically the effect of Ca 2+ oscillations on a particular example of cell regulation: the phosphorylation-dephosphorylation cycle controlling the activation of glycogen phosphorylase in hepatocytes. Methods The model of Ca 2+ oscillations was used. Results Ca 2+ oscillations could potentiate the response to a hormonal stimulation. Under the regulation of the kinetics of the phosphorylation dephosphorylation cycle in hepatocytes by Ca 2+ oscillations, the concentration of glycogen phosphorylase oscillated synchronously. Conclusion Ca 2+ oscillations in hepatocytes could contribute to the increase of the efficiency and specificity of cellular signaling.

关 键 词：肝细胞 Ca^2+振荡 磷酸化酶 动力学 数学模型 

分 类 号：R329.28[医药卫生—人体解剖和组织胚胎学]