纳米银纱布对海水及自来水浸泡的兔后肢枪伤伤道的治疗作用  

The therapeutic effect of nanometer silver impregnated dressing on gunshot wounds after being immersed in brine and tapwater in rabbits

作　　者：陈璧[1] 丁国斌[1] 汤朝武[1] 

机构地区：[1]第四军医大学西京医院烧伤科,西安710032

出　　处：《中华外科杂志》2004年第6期351-354,共4页Chinese Journal of Surgery

摘　　要：目的　观察纳米银纱布对海水及自来水浸泡的兔后肢枪伤伤道的治疗作用。方法　兔双后肢致枪伤后伤道分为 2组。组 1:伤道海水浸泡 5h ;组 2 :伤道自来水浸泡 5h。两组实验侧用纳米银纱布 ,对照侧用凡士林纱布换药治疗。各组均于浸泡后 30min和 1、2、3、4、5h取伤道组织活检 ,观察其病理改变。结果　组 1:实验侧较对照侧创周炎出现晚 ,程度轻 ,伤道内干燥 ,分泌物少。平均愈合时间 :实验侧入口 (2 9 4± 6 6 )d ,对照侧入口 (36 3± 6 0 )d (P <0 0 1) ;实验侧出口 (2 0 1± 6 0 )d ,对照侧出口 (2 7 3± 5 7)d (P <0 0 1)。组 2 :实验侧仅 1只兔创周轻度红肿 ,对照侧创周均有红肿 ,分泌物多。平均愈合时间 :实验侧入口 (13 0± 1 5 2 )d ,对照侧入口 (16 0± 3 10 )d(P <0 0 1) ;实验侧出口 (11 0± 2 75 )d ,对照侧出口 (15 6± 2 85 )d(P <0 0 1)。Objective To investigate the therapeutic effect of nanometer silver impregnated dressing on gunshot wounds after being immersed in brine and tapwater in rabbits Methods Rabbits were randomly divided into two groups after receiving gunshot wounds in both lower limbs In group 1,the wounded limbs on the experimental side were immersed in brine for 5 h; in group 2,the wounded limbs on experimental side were immersed in tapwater for 5 h All the wounds were treated with nanometer silver impregnated dressing on the experimental sides,while those of the control sides were treated with vaseline dressing Biopsy was done after 30 min and 1,2,3,4,5 h,respectively Results In group 1,the onset of inflammation around the wounds of the experimental sides was delayed,the inflammatory response was less serious,and the wounds were dry with less exudation compared to the controls The mean healing time of the entry wounds on experimental and control sides was (29 4±6 6) d and (36 3±6 0) d ( P <0 01),respectively,and that of the exit wounds on experimental and control sides was (20 1±6 0) d and (27 3±5 7) d ( P <0 01),respectively In group 2,only one of the experimental wounds showed mild inflammation,while all of the control wounds showed serious inflammation with much exudation The mean healing time of the entry wounds on experimentsides was (13 0±1 52) d ,while that on control sides was (16 0±3 10) d ( P <0 01) The mean healing time of exit wounds on experimental sides was (11 0±2 75) d,and those of the control sides was (15 6±2 85) d ( P <0 01) Conclusion The nanometer silver impregnated dressing can control infection and accelerate healing in gunshot wounds in rabbits

关 键 词：纳米银纱布 海水 自来水浸泡 兔 后肢 枪伤 伤道 治疗作用 

分 类 号：R82[医药卫生—临床医学]