原发性甲状旁腺机能亢进的骨骼MRI表现及诊断实验研究  

Experimental Study on Diagnostic Value of MRI in the Skeleton of Primary Hyperparathyroidism

作　　者：白荣杰[1] 柳淑云[2] 刘德新[2] 韩铭钧[1] 

机构地区：[1]中国医科大学附属第一医院放射科,沈阳110001 [2]黑龙江省大庆市第四医院,163712

出　　处：《中国医学影像学杂志》2004年第3期203-205,227,共4页Chinese Journal of Medical Imaging

摘　　要：目的 :探讨原发性甲状旁腺机能亢进 (Primaryhyperparathyroidism ,PHPT)骨骼病变的MRI特征性表现及其诊断价值。材料和方法 :健康成年中国白兔 80只 ,随机分成两组。对照组 40只 ,以正常饮食 (Ca :P =1:0 .7)喂养 ,实验组 40只 ,以高磷饮食 (Ca :P =1:7)喂养建立原发性甲状旁腺机能亢进动物模型。在第 3～ 6个月采用高场MR骨扫描分析影像学特征 ,并对甲状旁腺及骨骼行病理学检查 ,评价影像诊断的准确性。结果 :甲状旁腺明显增生。骨骼均存在骨质疏松表现 ,MRI(T1WI)表现为局限性低信号改变 ,T2WI早期表现为局限性低信号或高低混杂信号改变 ,相应螺旋CT扫描依次为阴性 ,可疑 ,骨质疏松 ,骨膜下皮质吸收表现。结论 :高场MR诊断早期PHPT骨骼病变的敏感性明显优于X线平片和CT ,是研究早期PHPT骨骼病变的可靠手段。Purpose: To study the MRI features of the skeleton of primary hyperparathyroidism (PHPT) and to correlate the findings of with that of pathology. Materials and Methods: 80 adult rabbits were divided into two groups. The animal model of PHPT was established by high phosphate diet induced(Ca:P,1:7) for 3-,4-,5-,or 6 month intervals. The imaging findings of the early PHPT were determined by using high-field MRI and spiral CT (SCT) scan at the 3th,4th,5th and 6th month. Rabbits were killed according to the imaging findings and histopathologic examination of the bone disease in PHPT were performed for evaluating the accuracy of imaging diagnosis. Results: Parathyroid histopathologic findings of PHPI appeared as region of hyperplasia,and the bone appeared osteoporosis. The osteopathy of PHPT displayed different degrees of low signal intensity on T1WI and low to high signal intensity on T2WI,but showed correspondingly negative,suspicions,osteoporosis on SCT scan in the same time. Conclusion: High-field MRI is superior to CT or conventional radiography in imaging diagnosis,it might be a reliable methods for the study of early osteopathy in PHPT.

关 键 词：原发性甲状旁腺机能亢进 骨骼 MRI 骨病 CT 

分 类 号：R581.1[医药卫生—内分泌] R445.2[医药卫生—内科学]