重组人骨形成蛋白-2复合1%透明质酸钠骨膜内诱导成骨的实验研究  

Experimental Research on Subperiosteal Induced Osteogenesis of rhBMP-2-1% Sodium Hyaluronate Compound

作　　者：张双越[1] 陈宁[1] 宋晓陵[2] 袁华[1] 

机构地区：[1]南京医科大学附属口腔医院口腔颌面外科,南京210029 [2]南京医科大学附属口腔医院病理科,南京210029

出　　处：《口腔医学》2004年第2期71-73,共3页Stomatology

基　　金：江苏省卫生厅科研基金资助项目 (H2 0 0 3 3 7)

摘　　要：目的　观察重组人骨形成蛋白 - 2 (rhBMP 2 )复合 1%透明质酸钠骨膜内诱导成骨的组织学过程 ,探讨其诱导成骨的机制。方法　将rhBMP - 2和 1%透明质酸钠复合后植入 9只新西兰大白兔胫骨骨膜下骨皮质的表面 ,对侧植入 1%透明质酸钠作为对照 ,分别于术后第 4、8、12周处死 3只动物取标本进行大体和组织学观察。结果　rhBMP - 2复合 1%透明质酸钠组骨膜内侧有明显的新骨形成 ,新骨呈渐进性的成熟过程 ,12周时和原有骨的组织结构一致。结论　rhBMP - 2和 1%透明质酸钠复合后可以用于骨缺损的修复。Objective To discuss the induced osteogenesis of rhBMP-2 by observing the histological process of subperiosteal induced bone formation of rhBMP-2-1% hyaluronic acid compound. Methods rhBMP-2 was combined with 1% hyaluronic acid(HA), and this compound was implanted to the cortical surface of one tibia of nine New Zealand rabbits as experimental group. The other tibia was implanted with 1% sodium hyaluronate as control group. The pathological reactions were observed at the intervals of 4,8 and 12 weeks after the implantation. Results In experimental group, the obvious new bone was observed, and the bone was gradually matured. At the 12th week after the implantation, the new bone was the same as the recipient bone. Conclusion This compound can be used as constructional material for bone defect.

关 键 词：重组人骨形成蛋白-2 透明质酸钠 诱导成骨 

分 类 号：R687.39[医药卫生—骨科学] R349.51[医药卫生—外科学]