Rho与中枢神经系统轴突再生  

Rho and Axonal Regeneration in The Central Nervous System

作　　者：于盼盼[1] 徐晓明[1] 陆佩华[1] 

机构地区：[1]上海第二医科大学神经生物学实验室,上海200025

出　　处：《生物化学与生物物理进展》2004年第4期296-298,共3页Progress In Biochemistry and Biophysics

摘　　要：Rho是小分子质量GTP酶Rho家族成员 ,在细胞的一些信号转导途径中起着分子开关的作用 .Rho能通过作用于肌动蛋白骨架系统引起轴突生长锥塌陷 ,从而抑制轴突生长 .研究表明 ,Nogo A、MAG、OMgp等髓鞘源性的轴突再生抑制分子均可通过激活Rho介导的信号转导途径抑制轴突再生 .Rho is a member of the Rho family of small GTPase, and acts as a molecular switch in some signal transduction pathway. Rho can induce growth cones collapse and inhibit axonal outgrowth by regulating the actin cytoskeleton. Recent studies have indicated that three myelin-derived inhibitors including Nogb-A, MAG and OMgp all can inhibit axonal regeneration by activating the Rho-mediated signal transduction pathway.

关 键 词：RHO GTP酶 中枢神经系统 轴突 再生 信号转导 

分 类 号：Q426[生物学—神经生物学]