痛立舒口服液的药理研究  

PHARMACOLOGICAL STUDY ON TONG LISHU ORAL SOLUTION

作　　者：黄爱平[1] 杨艳[1] 曾斌[1] 谢碧桃[1] 

机构地区：[1]泸州医学院药理学教研室

出　　处：《泸州医学院学报》1992年第4期260-264,共5页Journal of Luzhou Medical College

摘　　要：本文现察了痛立舒口服液对离体及在体兔肠平滑肌的作用,并观察了急性及长期毒性实验。结果表明:痛立舒能对抗ACh和BaCl_2以及毒扁豆硷等所致的肠平滑肌痉挛。急性毒性实验小鼠的最大耐受量相当于成人用量的450倍;长期毒性实验大鼠连续60天给药,不影响其生长发育,对血象及肝肾功能也未见不良影响,镜检表明,不损害心、肝、肾等主要实质器官。The action of Tong Lishu oral solutiou on rabbits' intestinal smooth muscle was observed in rive as well as in vitro and its acute and chronic tosicity was tested. The results indicated that the drug could anlagonize. The spasm of intestinal smooth muscle incluced by acetylcholine, barium chloride and Physostigmine. The mouse's maximum tolerance dose Was fouud to be equivalent to 450 times of man's commonly-used dose on the basis of acute toxicity experiment, while uuder chronic tosicity esperiment, havig been given to rats for 60 consecutive days, it didn't affect their growth, hemogram, as well as liver or kidney fuuction, and neither did it harm their parenchy-matous organs such as heart, liver, kidney, etc.

关 键 词：痛立舒 肠平滑肌 毒性 药理学 

分 类 号：R285.5[医药卫生—中药学]