Pt/C活性催化剂催化氢化合成6-氯-2-羟基喹喔啉  

Synthesis of 6-Chloro-2-hydroxyquinoxaline by Catalytic Hydrogenation with an Active Pt/C Catalyst

作　　者：刘国凯[1] 罗仕忠[1] 杨先贵[1] 王公应[1] 

机构地区：[1]中国科学院成都有机化学研究所,四川成都610041

出　　处：《农药》2004年第5期226-227,223,共3页Agrochemicals

摘　　要：以对氯邻硝基乙酰乙酰苯胺为原料 ,在碱性条件下经环合及催化氢化合成 6 氯 2 羟基喹喔啉。采用自制的Pt/C催化剂 ,考察了反应条件对产品收率的影响 ,在 85℃ ,1 0～ 1 3MPa氢气压力下进行加氢还原反应 ,总收率 89 6 % (以对氯邻硝基乙酰乙酰苯胺转化为 6 氯 2 羟基喹喔啉 )。Chloro-2-hydroxyquinoxaline was prepared from p-chloro-m-nitroacetoacetanilide through cyclization and catalytic hydrogenation in the presence of base. Laboratory synthesized Pt/C[ω(Pt)=5%] was used as the catalyst. Optimum conditions for the catalytic hydrogenation reaction were 85 to 90℃ and a hydrogen pressure of 1.0 to 1.3 MPa,providing a product yield of 89.6% (based on p-chloro-m-nitroacetoacetanilide).

关 键 词：活性催化剂 6-氯-2-羟基喹喔啉 对氯邻硝基乙酰乙酰苯胺 反应条件 收率 加氢还原反应 除草剂 

分 类 号：O626[理学—有机化学]