炒紫苏子醇提取物对小鼠智力的影响  

EFFCT OF ROASTED PERILLA SEED ALCOHOL EXTRACT ON MICE'S INTELLIGENCE

作　　者：张巍峨[1] 于超[1] 王钦富[1] 王永奇[1] 孙立智[2] 毕华[2] 

机构地区：[1]大连大学生物工程学院,大连116622 [2]大连大学医学检验专业,2002届学生大连116622

出　　处：《中国中医药科技》2004年第3期162-163,共2页Chinese Journal of Traditional Medical Science and Technology

基　　金：大连市科委资助项目No .SK2 0 0 10 5

摘　　要：目的 :研究炒紫苏子醇提取物对衰老小鼠智力的影响。方法 :将 10 0只 15月龄的老年小鼠与 2 0只 2 5日龄的青年小鼠随机分 6组 :青年组 ,老年衰老模型组 ,炒紫苏子醇提物 2 6 8mg/kg、134mg/kg、6 7mg/kg剂量组 ,脑复康组每组雌、雄各 10只。灌胃 2 1d后各组用Y -迷宫和跳台法对大鼠的学习记忆能力进行测定。结果 :炒紫苏子醇提物 3剂量组智力明显优于老年模型对照组 (P <0 0 1,P <0 0 1,P <0 0 5 ) ,智力与脑复康对照组接近 ,不同剂量组间有明显的剂量效应关系。结论Objective:To study the effect of roasted perilla seed alcohol extract on the intelligence of ageing mice.Methods:15-month-old mice and 25-day-old young mice were divided into groups as follows:young control,alcohol extract groups:(268mg/kg,134mg/kg,67mg/kg doses),Naofukang positive control.Each mouse was fed with EtOH ext.of roasted perilla seed and Naofukang 21 times(one time each day).The intelligence was detected by 'Y' Maze and Step Down Test. Results:The intelligence level in young control was the highest,while the aged control was the lowest among all the tested groups.Naofukang group as positive control,promoted significantly the ability of memory.The different doses of alcohol extract from roasted perilla seed,same as Naofukang group,could promote significantly the intelligence of mice,and there was a obviously good dose-effect relationship.Conclusion:The alcohol extract of roasted perilla seed could promote intelligence of aged mouse.

关 键 词：炒紫苏子醇 提取物 小鼠 智力 益智作用 中药 中医 

分 类 号：R285[医药卫生—中药学]