严重急性呼吸综合征患者血浆脂蛋白的变化特征  

A Study on the Plasma Lipids Levels of Severe Acute Respiratory Syndrome Patients

作　　者：尹志农[1] 何兴图[1] 常晓[1] 王红敏[1] 潘裕莹[1] 曾武威[2] 毕南[2] 薛红[2] 陈保生[2] 

机构地区：[1]北京市垂杨柳医院检验科,北京市100022 [2]中国医学科学院基础医学研究所,北京市100005

出　　处：《中国动脉硬化杂志》2004年第1期51-53,共3页Chinese Journal of Arteriosclerosis

基　　金：国家重点基础研究发展规划 ( 973 ) (G2 0 0 0 0 5 690 2 )

摘　　要：分析被冠状病毒感染患者血浆脂蛋白和载脂蛋白水平的变化。对 37例 (男 2 4例 ,女 13例 )严重急性呼吸综合征 (SARS)患者的血脂进行分析 ,并与 4 3例健康对照者相比较。结果发现 ,不论男性或女性 ,七项血脂指标中五项均明显低于对照组 ,它们是总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、载脂蛋白AⅠ和载脂蛋白B ,两组呈显著性差异 (P <0 .0 1)。在中西医结合治疗过程中 ,总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、载脂蛋白AⅠ和载脂蛋白B水平均逐步升高 ,康复出院时 ,上述主要指标达到正常指标水平。结果提示 ,五项主要血脂指标的同时升高可能预示患者将逐步康复。Aim Comparison of plasma lipids levels of severe acute respiratory syndrome (SARS) patients and control subjects. Methods plasma lipid and lipoprotein levels are reported. Results Compared with control, a marked reduction was observed in SARS group for total cholesterol (TC), low density lipoprotein cholesterol (LDLC), high density lipoprotein cholesterol (HDLC), apolipoprotein AⅠ(apo AⅠ) and apolipoprotein B (apo B) but not for triglyceride (TG) and lipoprotein a [Lp(a)]. Among the seven markers, reductions of HDLC and apo AⅠ were highly significant. HDLC in SARS individual is equal to 50% of that in control, and apo AⅠ 58.9%. Both LDLC and apo B reduced moderately by 35% and 30% each. However, there were no obvious differences in Lp(a) between two groups that suggested that is level might not been affected by the coronavirus. Continuous measurements were provided to several patients to monitor the dynamic variation of lipids and lipoproteins in plasma. The major components of plasma lipoprotein were lower than normal before treatment. While after a therapeutic alliance of traditional Chinese medicine and western medicine, lipoprotein levels of TC, HDLC, LDLC, apo AⅠ and apo B have increased significantly. Conclusions The rise of the five major serum lipids measurements may predict that the patients will be restored to health gradually.

关 键 词：生物化学 严重急性呼吸综合征患者血浆脂蛋白的变化特征 免疫比浊法 免疫比浊法 冠状病毒 总胆固醇 脂蛋白 载脂蛋白 

分 类 号：Q5[生物学—生物化学]