丙磺舒增强丙戊酸抗癫痫作用的试探性研究  

A study of enhencing antiepileptic effect of probenecid on valproic acid

作　　者：孙红斌[1] 沈鼎烈[1] 

机构地区：[1]重庆医科大学附一院神经科

出　　处：《临床神经病学杂志》1992年第3期142-143,共2页Journal of Clinical Neurology

摘　　要：本文研究了丙磺舒增强丙戊酸(VPA)的脑内作用,提示在VPA与丙磺舒合用后能显著提高CSF中的VPA浓度,而血中总浓度、游离浓度无显著性改变。本组12例病人在加用丙磺舒后使CSF中VPA浓度提高26～170％,6例癲痫发作频率显著减少,无明显副作用。它可能成为增强VPA脑内抗癲痫作用的一个重要途径。This study reported 12 eases of epilepsy being treated in combination with Valproic acid (VPA) and probenecid. The results showed the concentration of VPA in cerebrospinal fluid being enheneed by 26～170%, but the VPA concentration total and free in plasma revealed no change, In 6 of these cases, the frequency of seizures was signifieantly reduced anti no side effects was occurred. It is possible to become an important method of enhencing antiepileptic effect on VPA.

关 键 词：丙戊酸 丙磺舒 癫痫 

分 类 号：R971.6[医药卫生—药品] R742.105[医药卫生—药学]