早产儿坏死性小肠结肠炎临床流行病学特点  

EPIDEMIOLOGICAL FEATURES OF PRETERM INFANTS NECROTIZING ENTEROCOLITIS

作　　者：吴莉[1] 陈豪[1] 徐秋玲[1] 印学蕾[1] 陆国强[2] 杨弘伟[3] 顾爱珠[4] 

机构地区：[1]上海市第一妇婴保健院新生儿科暨上海市早产儿医疗护理中心,200040 [2]上海市第一妇婴保健院放射科暨上海市早产儿医疗护理中心,200040 [3]上海市第一妇婴保健院新生儿科暨上海市早产儿医疗护理中心放射科,放射科200040 [4]上海市第一妇婴保健院暨上海市早产儿医疗护理中心放射科,200040

出　　处：《新生儿科杂志》2004年第2期58-61,96,共5页The Journal of Neonatology

摘　　要：目的 对上海市早产儿中心近10年间NEC临床流行病学特点进行分析,旨在加强对本病的进一步认识,早期诊断,早期干预,进一步提高早产儿存活率。方法调查1993年1月1日～2002年12月31日出生的1869例早产儿,对确诊NEC的59例临床资料进行比较分析,寻找引起NEC可能的相关因素。结果 早产儿NEC发生率为3.16％。胎龄小、体重低、胃肠道动力功能差及局部免疫应答能力低下、感染仍是NEC发病重要的影响因素。临床分度与预后密切相关。结论 减少早产儿发生率是降低NEC发病率的最好办法。加强早产儿的护理,实施正确喂养方案,促进胃肠蠕动功能,及时发现和控制感染是十分重要的预防措施。何时恢复喂养需谨慎判断。Objective To investigate the epidemiological features of preterm infants necrotizing enterocolitis (NEC) in the recent decade. Method The records of 59 preterm infants with necrotizing enterocolitis diagnosed among 1869 premature infants admitted to NICU from January 1, 1993 to December 31, 2002 were reviewed, analysed the risk factors for NEC. Results The incidence of preterm infants necrotizing enterocolitis in our data was 3.16% (59/1869). Risk factors including the prematurity, low birth weight, immature intestinal immune function and poor motility, and bacterial infection bad been associated with the development of NEC. The severe NEC with stage2 and stage3 showed a bad prognosis. Conclusion It should be the best way for preventing NEC to reduce the birth rate of preterm infants. Our results indicated that strengthening nursing, implementing the correct feeding schedules, improving bowel movement and controling bacteria infection were necessary against NEC in premature neonates.

关 键 词：早产儿 坏死性小肠结肠炎 流行病学 NEC 

分 类 号：R722.6[医药卫生—儿科]