长沙地区泌尿生殖道支原体感染及其耐药性分析(英文)  

Analysis of infection patterns and drug resistance of urogenital mycoplasma in Changsha district

作　　者：廖朝晖[1] 鲁建云[1] 陈静[1] 左成忻[1] 严开林[1] 黄进华[1] 

机构地区：[1]中南大学湘雅三医院皮肤科,湖南长沙410013

出　　处：《中国现代医学杂志》2004年第9期49-51,共3页China Journal of Modern Medicine

摘　　要：目的　了解长沙地区性病门诊患者中支原体的感染及其耐药情况 ,为临床治疗支原体感染提供药物选择参考。方法　采用支原体培养法对 181例患者的泌尿生殖道标本进行解脲支原体 (Uu)和人型支原体(Mh)培养和药物敏感性检测。结果　 181例患者中有 79例分离出支原体 ,分离率为 4 3.6 % ,其中Uu阳性占2 6 .5 % ,Nh阳性占 3.3% ,混合感染占 13.8% ;女性支原体分离率显著高于男性 (5 8.6 %vs 36 .6 % ,χ2 =6 .91,P<0 .0 1) ;女性混合感染率亦明显高于男性 (2 2 .4 %vs 9.8% ,χ2 =4 .2 9,P <0 .0 5 ) ;阳性患者主要分布于 2 0～ 39岁年龄段 ;支原体对环丙沙星、氧氟沙星、红霉素、罗红霉素、阿齐霉素、强力霉素、美满霉素和交沙霉素的耐药率依次为 84 .8%、4 4 .3%、30 .4 %、2 2 .8%、19.0 %、15 .2 %、11.4 %和 2 .5 %。结论　泌尿生殖道支原体感染以Uu为主 ,其次为Uu +Mh混合感染 ;女性感染率高于男性 ;支原体感染率与性活跃程度有关。长沙地区治疗支原体感染首选交沙霉素、美满霉素。Objective:To investigate the infection patterns of urogenital mycoplasma and to analyze the drug resistance of the mycoplasma in Changsha district.Methods:The mycoplasma culture was done in specimens from 181 STD clinic patients with urogenital tract infection and the drug sensitivity test was performed.Results:Seventy-nine of 181 patients were mycoplasma positive, and the infection rate was 43.6%. Among them, 26.5% were ureaplasma urealyticum (Uu) positive, 3.3% were mycoplasma hominis(Mh) positive and 13.8% were both Uu and Mh positive. In addition, the mycoplasma infection rate in females was significantly higher than that in males (58.6% vs 36.6%, χ 2=6.91, P <0.01).Furthermore, the rate of mixed infection in females was significantly higher than that in males(22.4% vs 9.8%, χ 2=4.29, P <0.05).Most of the patients infected with mycoplasma were 20～39 years old. The drug resistance rates of mycoplasma to ciprofloxacin, ofloxacin, erythromycin, roxithromycin, azithromycin, deoxycycline, minocycline and josamycin were 84.8%, 44.3%, 30.4%, 22.8%, 19.0%, 15.2%, 11.4% and 2.5%, respectively. Conclusions:The urogenital tract infections of mycoplasma result mainly from Uu, secondly from mixed Uu and Mh. Females are infected more often than males. Mycoplasma infections are related to sexual activity. To treat mycoplasma infections in Changsha district, josamycin, minocycline, deoxycycline and azithromycin are recommended.

关 键 词：泌尿生殖道感染 支原体 药物敏感性 

分 类 号：R446.5[医药卫生—诊断学]