咪唑斯汀对花生四烯酸诱导的鼠爪水肿的影响  

Influences of Mizolastine on Rat Paw Edema Induced by Arachidonic Acid

作　　者：付萌[1] 张衍国[1] 刘玉峰[1] 王志鹏[2] 张鑫[3] 杜俊峰[3] 

机构地区：[1]第四军医大学西京医院全军皮肤性病中心,西安710032 [2]第四军医大学基础部药理学教研室 [3]第四军医大学学员旅

出　　处：《中华皮肤科杂志》2003年第10期591-592,共2页Chinese Journal of Dermatology

摘　　要：目的 探讨咪唑斯汀抗炎活性的产生机制。方法 大鼠鼠爪皮下注射0.1 mL的花生四烯酸(体积分数为0.003)诱导鼠爪水肿炎性动物模型。注射前灌胃分别给予咪唑斯汀、氯雷他定、西替利嗪(0.3 mg/kg),用千分尺测量肿胀足爪厚度,比较不同抗组胺药对鼠爪肿胀抑制程度的高低。分别给予大鼠5-脂氧合酶的直接抑制剂齐留通(3 mg/kg)和咪唑斯汀(0.3 mg/kg),比较2种药物对鼠爪肿胀抑制程度的高低。结果 咪唑斯汀显著抑制花生四烯酸诱导的鼠爪水肿,氯雷他定、西替利嗪对鼠爪水肿无抑制作用(P<0.01);齐留通显著抑制鼠爪水肿(P<0.01),对鼠爪水肿的抑制率与咪唑斯汀比较差异无显著性(P>0.05)。结论 咪唑斯汀可能通过抑制5-脂氧合酶活性的途径发挥其抗炎活性。Objective To investigate the anti-inflammatory properties of mizolastine and explore its possible mechanisms. Methods Edema at hind-paw of rat was induced by a single injection of arachidonic acid(AA), each containing 0.1 mL of prepared AA(0.3%). The intensity of AA-induced reactions was ex-pressed as an increasing of rat paw thickness, which was measured by micrometer. After the drugs (mizolastine, loratadine, cetirizine) were given orally separately, the inhibitory effects were determined by the de-creasing of edema intensity. Zileuton and mizolastine were given orally separately and the inhibitory effects were compared subsequently. Results The intensity of AA-induced edema was significantly inhibited by mizolastine, but not by loratadine or cetirizine There was no significant difference between mizolastine and zileuton in the inhibition of AA-induced edema. Conclusion Mizolastine possesses anti-inflammatory properties in vivo, which may be related to the inhibition of the 5-lipogenase pathway.

关 键 词：咪唑斯汀 花生四烯酸诱导 鼠爪水肿 荨麻疹 治疗效果 

分 类 号：R965[医药卫生—药理学]