川芎嗪对溃疡性结肠炎患者血栓素B_2、6-酮-前列腺素F1α的影响  

Effect of Tetramethylpyrazine on Plasma Thyromboxane B_2,6-keto-prostaglan-din F1α in Patients with Ulcerative Colitis

作　　者：陈维雄[1] 陈金联[1] 陈尼维[1] 金涌[1] 达炜[1] 

机构地区：[1]上海交通大学附属第六人民医院消化科,上海200233

出　　处：《中国临床医学》2004年第2期166-167,176,共3页Chinese Journal of Clinical Medicine

基　　金：上海市卫生局基金资助(No.01443)

摘　　要：目的:研究川芎嗪对溃疡性结肠炎(ulcerative colitis,UC)患者血栓素B2(TXB2)及6-酮-前列腺素F1α(6-keto-PGF1α)的影响及其治疗作用。方法:27例UC患者,其中轻中度患者13例,重度患者14例。其中轻中度患者随机分为川芎嗪+SASP组(n=6)与SASP组(n=7),重度患者分为川芎嗪+激素组(n=7)与激素组(n=7)。疗程为10d。治疗前、后用放免法测定血浆TXB2及6-keto-PGF1α含量,并观察疾病活动指数(DAI)和病理学评分的变化。结果:川芎嗪组与SASP或激素对照组相比,川芎嗪组DAI和病理学评分明显改善;且血浆TXB2、TXB2/6-keto-PGF1α明显下降(P<0.01);6-keto-PGF1α明显上升(P<0.01)。结论:川芎嗪能抗血小板、保护血管内皮细胞功能,对UC具有一定的治疗作用。Objective: To study the effect of tetramethylpyrazine (TMP) on plasma thyromboxane B2 (TXB2),6-keto-pros-taglandin F1α(6-keto- PGF1α) and its treatment in patients with ulcerative colitis. Methods: There were 27 cases of ulcera-tive colitis, 13 cases with mild or moderate ulcerative colitis were divided into two groups(TMPgroup and control group).14 cases with severe ulcerative colitis were divided into two groups (TMP group and control group). Disease activity index(DAI), pathologic scores and plasma concentration of TXB2 and 6-keto-PGF1α were detected before and after treatment of all cases. Results: Treatment with TMP significantly attenuated colonic damage and DAI. TXB2, TXB2/6-keto-PGF1α decreased, and 6-keto-PGF1α increased after treatment of TMP, whereas there did not differ in control group. Conclusion: TMP may be useful in treatment of ulcerative colitis through antiplatelet and protection of endothelial cells.

关 键 词：川芎嗪 溃疡性结肠炎 血栓素B2 6-酮-前列腺素F1Α 药物治疗 

分 类 号：R259.756.2[医药卫生—中西医结合]