高血压患者血压正常子女的运动肾显像研究  

Exercise scintirenography in normotensive young offspring of essential hypertensives

作　　者：孔繁振[1] 张承刚[1] 赵德善[1] 

机构地区：[1]山西医科大学第一医院核医学科

出　　处：《中华核医学杂志》2004年第2期85-88,i001,共5页Chinese Journal of Nuclear Medicine

摘　　要：目的　观察原发性高血压 (EH)患者其血压正常子女 (NOH)是否存在潜在的、与遗传有关的肾功能损伤并探讨导致该异常的可能机理。方法　分别对 31例NOH、31例无高血压家族史的血压正常年轻人 (NON)、2 1例高血压双亲及 10例血压正常的老年人进行静息与运动介入99Tcm DTPA动态肾显像。结果　NOH组静息双侧肾脏高峰时间、平均通过时间比NON组显著延长 ;运动状态下此差异更为显著 ,且肾小球滤过率、肾脏指数显著低于NON组 ,2 0min计数 高峰计数比值比NON组显著增高 ;上述各组分别有 4 ,0 ,5 ,2例受试者出现明显异常的运动肾显像。结论　NOH存在潜在的、与遗传有关的肾功能损伤 ;肾脏在EH的遗传和发病中可能起重要作用。Objective To observe whether there is potential renal function decline in normotensive young offspring of essential hypertensives and to probe into the possible mechanism giving rise to it,providing some clues to the study of the pathogenic and hereditary mechanism of essential hypertension. Methods Using 99 Tc m-DTPA as the imaging agent,we performed rest and exercise scintirenography in normotensive young offspring of essential hypertensives [NOH,31 cases,14 males,17 females;mean age: (23.2±4.1) years],normotensive young offspring of non-hypertensives [NON,31 cases,20 males,11 females;mean age: (23.1±3.6) years],some of the hypertensive parents [21 cases,5 males,16 females;mean age: (53.0±5.61) years] and old non-hypertensive subjects [10 cases,6 males,4 females;mean age: (53.7±5.2) years]. The results were analyzed with the software of SPSS 10.0 for Windows. Results Though all of the rest renal function indexes from NOH were within the normal range,there were significant differences between most of those indexes from NOH and those from NON,e.g.,t p and MTT from NOH were significantly delayed than those from NON;exercise made these differences more significant,and after exercise,glomerular filtration rate (GFR) and RI were significantly lower,and 20/P was significantly higher. There were 4,5,2 cases showing abnormal exercise scintirenography in NOH,hypertensive parents and old non-hypertensive subjects,respectively,but none in NON group. Conclusions There is potential renal function decline in normotensive young offspring of essential hypertensives. The kidney may play an important role in the pathogenic and hereditary mechanism of essential hypertension.

关 键 词：高血压 放射性核素显像 肾功能试验 D1PA 

分 类 号：R817.4[医药卫生—影像医学与核医学]