心肌造影超声心动图诊断犬急性高血糖心肌微血管功能损害的实验研究  

Experimental study of myocardial microvascular impairment by myocardial contrast echocardiography in acute hyperglycemic dogs

作　　者：迟东升[1] 刘伊丽[1] 刘俭[1] 陈小林[1] 王鹏[1] 冯金华[1] 

机构地区：[1]第一军医大学附属南方医院心内科

出　　处：《中华超声影像学杂志》2004年第4期284-287,共4页Chinese Journal of Ultrasonography

基　　金：军队九五重点课题 (98Z0 72 );十五重点课题 (0 1Z0 52 )

摘　　要：目的　探讨犬急性高血糖对冠状动脉和心肌微血管血流量及血流储备的影响。方法　 16条杂种犬 ,静脉注射双嘧达莫前后 ,应用血流仪和心肌造影超声心动图 (MCE)测量基础状态和高血糖状态时冠状动脉前降支和心肌微血管的血流量。结果　应用双嘧达莫前 ,基础状态和高血糖状态的前降支和心肌微血管的血流量 [( 13 .94± 2 .92 )ml/min对 ( 15 .0 5± 8.61)ml/min和 ( 4 5 .49± 14 .2 8)ml/min对 ( 4 8.62± 2 9.5 9)ml/min ,P >0 .0 5 ]以及微血管密度 ( 5 7.0 5± 7.87对 68.65± 10 .0 0 ,P >0 .0 5 )均差异无显著性意义 ;应用双嘧达莫后 ,前降支血流量和血流储备无明显变化 ,而心肌微血管的血流量 [( 91.71± 42 .67)ml/min对 ( 4 1.16± 2 3 .15 )ml/min ,P <0 .0 1]、血流速度 [( 1.11± 0 .61)ml/min对 ( 0 .67± 0 .2 7)ml/min ,P <0 .0 5 )、血管密度 ( 86.78± 2 1.84对 65 .18± 2 8.5 8,P <0 .0 1)和血流储备 ( 2 .15± 1.3 0对 0 .84±0 .44 ,P <0 .0 1)明显下降。结论　急性高血糖减少双嘧达莫负荷后的心肌微血管的血流量、血流储备和血管密度。Objective To investigate the influence of acute hyperglycemia on coronary blood flow(CBF) and coronary flow reserve(CFR) of left anterior descending coronary artery(LAD) and myocardial microvessels. Methods The CBF of LAD and myocardial microvessels were measured with flowmeter and myocardial contrast echocardiography (MCE) before and after dipyridamole intravenous administration in basal and hyperglycemia state. Results Before intravenous administration of dipyridamole, the CBF of LAD and myocardial microvessels[( 13.94± 2.92)ml/min vs ( 15.05± 8.61)ml/min and ( 45.49± 14.28)ml/min vs ( 48.62± 29.59)ml/min, P> 0.05] and density of myocardial microvessels [( 57.05± 7.87)ml/min vs ( 68.65±10.00)ml/min,P> 0.05)] were comparable. After dipyridamole administration, CBF and CFR of LAD had no change, but CBF[( 91.71± 42.67)ml/min vs ( 41.16± 23.15)ml/min, P< 0.01], blood flow velocity [( 1.11± 0.61)ml/min vs ( 0.67± 0.27)ml/min, P< 0.05)], density( 86.78± 21.84 vs 65.18± 28.58,P< 0.01) and CFR of myocardial microvessels( 2.15± 1.30 vs 0.84± 0.44,P< 0.01) reduced obviously. Conclusions Acute hyperglycemia impairs CBF,CFR and reduces density and blood velocity of myocardial microvessels.

关 键 词：心肌造影 超声心动图 诊断 犬 急性高血糖 心肌微血管功能损害 实验 

分 类 号：R445.1[医药卫生—影像医学与核医学]