氯沙坦对自发性高血压大鼠主动脉内膜ICAM-1和PAI-1表达的影响  

The Effect of Losartan on Expression of ICAM-1 and PAI-1 on Aortic Intima of Spontaneously Hypertensive Rats

作　　者：黄俊[1] 刘昌慧[1] 张黎军[1] 

机构地区：[1]武汉大学人民医院老年病科,邮政编码武汉430060

出　　处：《微循环学杂志》2004年第2期30-31,34,F004,共4页Chinese Journal of Microcirculation

摘　　要：目的 :比较早期雄性自发性高血压大鼠 (SHR)和正常雄性同周龄WistarKyoto大鼠 (WKY)主动脉内膜细胞间粘附分子 1(ICAM 1)和纤溶酶原激活物抑制剂 1(PAI 1)的表达及氯沙坦对其的影响。方法 :将 2 0只雄性SHR随机分成二组 ,每组 10只 ,其中一组灌喂氯沙坦 2 0mg/kg/天 ,另一对照组给正常饮水 ,共 12周 ,并与WKY 10只比较。采用免疫组织化学方法检测三组大鼠主动脉内膜ICAM 1和PAI 1的表达。结果 :与WKY大鼠比较 ,SHR对照组主动脉内膜ICAM 1和PAI 1表达明显增高 ;经氯沙坦治疗 12周后SHR血压显著降低 ,主动脉内膜ICAM 1和PAI 1表达亦明显下降。结论 :氯沙坦在有效降压的同时也明显抑制SHR主动脉内膜ICAM 1和PAI 1的表达 ,提示氯沙坦作为血管紧张素II受体 1拮抗剂 (AT1 R)Objective: To probe into the effect of Losartan on expression of intercellular adhesion molecule-1(ICAM-1) and plasminogen activitor inhibitor-1(PAI-1) on aortic intima of early Spontaneously Hypertensive rats(SHR).Method: Twenty SHR were divided randomizedly into 2 groups of 10 rats each. One group is fed with Losartan of 20 mg/kg/d for 12 weeks,while the remained group (SHR control group) and 10 Wistar Kyoto rats(WKY) were given normol water only for equal time. The expressions of ICAM-1 and PAI-1 on aortic intima of three groups rats were studied by immunohistochemistery.Results: The expression of ICAM-1 and PAI-1 on aortic intima of SHR control group is higher than WKY group. It is shown markly lower expressions in Losartan group than that in SHR control group, and the blood pressure is decreased significantly.Conclusion: Losartan has the suppressing effects on the expressions of ICAM-1 and PAI-1. It suggest that AT 1 receptor antaginist will reverse the damage of target organ in patients with essential hypertension.

关 键 词：氯沙坦 自发性高血压 大鼠 主动脉内膜 ICAM-1 PAI-1 并发症 免疫组织 

分 类 号：R544.1[医药卫生—心血管疾病] R-332[医药卫生—内科学]