老年气虚血瘀证患者微循环和血液流变学特征及通心络胶囊的治疗作用观察  

Observation of Characteristic of Hemorrheology and Nailfold Microcirculation in Old Patients with Qi-deficiency Causing Blood Stasis Syndrome and Effect of Capsule Tongxinluo for the Treatment

作　　者：吴汉卿[1] 黄召谊[1] 杨芙蓉[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院,邮政编码武汉430030

出　　处：《微循环学杂志》2004年第2期13-15,共3页Chinese Journal of Microcirculation

摘　　要：目的 :观察老年气虚血瘀证患者甲襞微循环和血液流变性特征及通心络胶囊的治疗作用。方法 :选择年龄 60岁以上的心、脑血管疾病患者 (中医辨证属气虚血瘀型 ) 60例 ,检测微循环和血液流变学指标 ,再随机分为治疗组 (通心络胶囊组 ) 3 3例和对照组 (尼莫地平组 ) 2 7例作比较 ,观察通心络胶囊对改善微循环和血液流变性及临床症状的治疗作用。结果 :气虚血瘀症患者治疗前甲襞微循环中度及重度异常者 5 2例 ( 86.67% ,5 2 /60 ) ,其中治疗组 2 9例 ( 87.9% ,2 9/3 3 ) ,对照组2 3例 ( 85 .7% ,2 3 /2 7) ,以形态积分 ( 2 .5 8) >流态积分 ( 2 .2 2 ) >袢周积分 ( 0 .83 )为主要特征 ;血液流变学指标两组异常率同为 10 0 % ,其中以全血粘度、血浆粘度、红细胞聚集指数明显升高 ,红细胞变形能力降低为主要特征。治疗 3 0天后 ,微循环及血液流变学指标较治疗前均有显著改善 (P均 <0 .0 5～ 0 .0 1)。并且治疗组与对照组比较均有显著差异 (P <0 .0 5 )。临床治疗总有效率 ,治疗组为 90 .9% ,对照组为 70 .3 9 % ,两组比较有显著性差异 (P <0 .0 5 )。结论 :老年气虚血瘀证患者甲襞微循环异常和血液流变学指标异常率极高 。Objective: To observe the characteristic of hemorrheology and microcirculation in patients with Qi-deficiency causing blood stasis syndrome and the effect of capsule Tongxinluo for the treatment.Method: 60 patient with cardiovascular or/and cerebral vessels diseases were randomized into treatment group (Tongxinluo group,33 cases) and control group (Nimodipine group,27 cases).Before treatment and after 30 days' treatment with capsule Tongxinluo and capsule Nimodipine respictively,two group′s nailfold microcirculation?blood viscosity and main clinical symptoms were all observed.Results: Before treatment,nailfold microcirculation is middling and serious abnormalism the main nailfold microcirculation characteristic is shape integral(2.58)>fluid state integral(2.22)>perivascular integral(0.83). The items of hemorrheology of all patients have serious abnormal.The main hemorrheology characteristic is blood viscosity(BV),plasma viscosity(PV) and red blood cell aggregation index(RAI) heighten obviously, and red blood cell deformation index(RDI) lower obviously. After 30 days' treatment all items of hemorrheology and nailfold microcirculation has obvious amelioration(P<0.05～0.01),there is statistical significant difference between the two groups .The effective rate of main clinical symptoms for the treatment group is 90.9%, and the control group is 70.39%(P<0.05).Conclusion: The abnormal ratio of nailfold microcirculation and the items of hemorrheology to old patients with Qi-deficiency causing blood stasis syndrome are very high(100%),but capsule Tongxinluo has good effects to ameliorate the human microcirculation and reduce the blood viscosity.

关 键 词：老年人 气虚血瘀证 微循环 血液流变学 通心络胶囊 中医 脑血管病 

分 类 号：R286[医药卫生—中药学]