新生儿肺炎白细胞介素-10、-13与免疫球蛋白的关系  

Relationship between interleukin-10,interleukin-13 and immunoglobulins in infants with infectious pneumonia

作　　者：陈昌辉[1] 李茂军[1] 叶长宁[1] 邱练芬[1] 毛晓兰[2] 陈丽娜[1] 阳倩[1] 何海兰[1] 

机构地区：[1]四川省医学科学院四川省人民医院,四川成都610072 [2]成都市妇产科医院,四川成都610015

出　　处：《实用儿科临床杂志》2004年第5期380-382,共3页Journal of Applied Clinical Pediatrics

基　　金：四川省卫生厅科研基金资助项目 (0 0 0 0 92 )

摘　　要：目的　探讨新生儿肺炎白细胞介素 (IL) 10、 13与免疫球蛋白 (Ig)的关系。 方法　采用免疫酶法(ELISA)和速率散射比浊法检测新生儿肺炎患儿血IL 10、IL 13、IgG、IgA、IgM。以C反应蛋白 (CRP)≥ 2 0mg/L作为诊断细菌感染的界限值 ,结合临床资料 ,将肺炎分为 4组进行结果分析。结果　 1.肺炎组 8型常见病毒及支原体特异性IgM阳性 4 0份 (36 .0 % ) ;对照组 30份血清检测均阴性。病毒及支原体感染 (病毒感染 ) 2 3例(2 0 .7% ) ,细菌感染 4 5例 (4 0 .5 % ) ,混合感染 17例 (15 .3% ) ,不明病原感染 (其他感染 ) 2 6例 (2 3.4 % )。 2 .肺炎组IgA、IgM明显高于对照组 (P <0 .0 5 )。其中病毒感染组IgA明显高于其他感染组和对照组 (P <0 .0 5 ) ;IgM含量为细菌感染组显著高于对照组 (P <0 .0 5 )。 3.病毒感染组IgG、IgA、IgM分别与IL 10有显著相关 (P<0 .0 5 )。混合感染组、细菌感染组和对照组IgM分别与其IL 13呈显著相关 (P <0 .0 5 )。结论　新生儿肺炎时 ,IgA是完成抗病毒体液免疫应答的重要成分 ,IL 10对IgA产生具有调节作用 ;IgM能在抗菌性体液免疫机制中发挥重要作用 ,ILObjective To explore the relationship between interleukin(IL)-10,IL-13 and immunoglobulins in infants with infectious pneumonia.Methods Serum IL-10,IL-13,IgG,IgA,IgM were detected by ELISA and rate scattered nephelometry in infants with infectious pneumonia and control infants.If serum concentration was more than 20 mg/L,infants were defined as bacterial infection by other clinical data.All the infants with pneumonia were divided into 4 groups,then results were analyzed.Results Fourty cases (36.0 %) were positive special serum IgM in pneumonias group while all were negative in control group.Twenty-three (20.7 %) were probably infected by viruses and mycoplasmas,45 (40.5 %) bacteria,17(15.3 %) both of viruses and mycoplasmas complicated bacteria,26(23.4 %) other pathogen;2.serum IgA,IgM concentration of pneumonia group were higher than those of the controls.Among them,IgA of infants with viral and mycoplasmal pneumonia was higher than that of the other pneumonia and the controls;IgM with bacterial pneumonias was higher than that of the controls;3.there was positive correlation between serum IgG,IgA,IgM and IL-10 respectively in the group infected by viruses and mycoplasmas;there was positive correlation between serum IgM and IL-13 in the group infected by both viruses and mycoplasmas complicated bacteria,bacteria group and control group respectively.Conclusions When infants suffer from infectious pneumonia, IgA plays an important role in anti-viral humoral immunity;IL-10 may perform immuno-regulatory function in the production of IgA ; IgM plays an important part in anti-bacterial humoral immunity,and IL-13 may regulate the production of IgM.

关 键 词：新生儿 肺炎 白细胞介素-10 白细胞介素-13 免疫球蛋白 

分 类 号：R722.135[医药卫生—儿科]