睡眠呼吸暂停低通气综合征患者肺功能脉冲强迫振荡检测数据变化的意义  

Change and significance of values of impulse oscillometry in obstructive sleep apnea and hypopnea syndrome patients

作　　者：潘文森[1] 郝树亭[1] 袁雅冬[1] 

机构地区：[1]河北医科大学第二医院呼吸内科,河北石家庄050000

出　　处：《临床荟萃》2004年第10期548-550,共3页Clinical Focus

摘　　要：目的　观察阻塞性睡眠呼吸暂停低通气综合征 (OSAHS)患者肺功能检查中脉冲强迫振荡 (IOS)检测数据的变化 ,并探讨其临床意义。方法　对 2 4例OSAHS患者 (OSAHS组 )和 12名正常人 (对照组 )进行常规肺功能及脉冲强迫振荡 (IOS)检测。结果　OSAHS组中心气道阻抗 (CAI)和上气道阻力 (R35 )明显高于对照组 ,差异有统计学意义 (P <0 .0 1) ,中心气道阻力 (R2 0 )和外周气道阻力 (R5～R2 0 )也高于对照组 ,差异亦有统计学意义 (P <0 .0 5 ) ;将OSAHS组睡眠监测指标与IOS测定指标相关性进行研究 ,发现呼吸暂停低通气指数 (AHI)与CAI和R35呈正相关 ,相关系数 (r)分别为 0 .6 5和 0 .6 6 (P <0 .0 1) ;夜间最低血氧饱和度 (SO2 )与CAI和R35呈负相关 ,r分别为- 0 .6 6和 - 0 .6 5 (P <0 .0 1)。结论　IOS技术可作为检测OSAHS患者上气道阻力的一种方法 ,并且有助于其病理机制的探讨。Objective To observe the change of values of impulse oscillometry in obstructive sleep apnea and hypopnea syndrome(OSAHS) patients and their clinical significance. Methods Routine lung function and impulse oscillometry(IOS) were performed on 24 OSAHS patients(OSAHS group) and 12 normal subjects(control group).Results Central airway impedance(CAI) and upper airway resistance(R35) in OSAHS group were significantly higher than the ones in control group (P< 0.01), central airway resistance(R20) and peripheral airway resistance(R5-R20) of the former showed more significant difference than those of the latter (P< 0.05). Using correlations analysis between the sleep monitoring items and IOS items in OSAHS group,apnea hypopnea index(AHI) showed positive correlations with CAI and R35,with correlation coefficient(r) respectively 0.65 and 0.66 (P< 0.01). The lowest nocturnal O 2 saturation(SO 2) had negative correlations with CAI and R35,r respectively -0.66 and -0.65 (P< 0.01). Conclusion IOS technique can be a method for assessing the patients' upper airway obstruction,and is helpful in exploration of the pathological mechanism.

关 键 词：睡眠呼吸暂停综合征 脉冲强迫振荡 气道阻力 

分 类 号：R563[医药卫生—呼吸系统]