复脉Ⅰ号抗应激豚鼠在体心脏触发活动的实验研究  

Experimental Studies of Fumai Ⅰ on Thiggered Activity Induced by Stress in Guinea Pig in Vivo

作　　者：李文宏[1] 周青罡[1] 廖群[1] 陈奇[1] 

机构地区：[1]江西中医学院药学系,江西南昌330006

出　　处：《中国实验方剂学杂志》2004年第3期33-36,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：江西省自然基金课题 (0 1 4 0 0 1 0 ) ;江西省教育厅课题(赣教批字 2 0 0 1年 387号文 )

摘　　要：目的 :研究复脉Ⅰ号对应激性心律失常、心肌损伤的保护作用及机制。方法 :用电刺激方法制备慢性应激模型 ,异丙肾上腺素激发 ,同步观察ECG及在体心脏心外膜单相动作电位 (MAP) ,并测定心肌组织中乳酸脱氢酶 (LDH)、肌酸激酶 (CK)、一氧化氮合酶 (NOS)的活性和一氧化氮 (NO)的含量。结果 :复脉Ⅰ号能降低应激豚鼠在体心脏触发活动及心律失常的发生率 ,并能降低心肌组织中LDH、NOS的活性 ,减少NO的含量 ,减少心肌CK的释放。结论 :复脉Ⅰ号对应激性必律失常和心肌损伤有明显的保护作用。Objectives:To observe the protective effects and mechanism of Fumai Ⅰ on arrhythmias and myocardial injury induced by stress. Methods: Chronic stress guinea pig model was established by footshock during a long period,arrhythmias was induced by Isoprenaline,epicardial Monophasic action potential (MAP) and ECG were detected synchronously, the activities of LDH,CK,NOS and the content of NO in myocarditis were measured. Results: Fumai Ⅰ can reduce the incidences of arrhythmias and triggered activity,the activity of LDH,NOS and the content of NO,increased the activity of CK in myocardium. Conclution:Fumai Ⅰ has a protective effect on arrhythmias and myocardial injury induced by stress.

关 键 词：复脉Ⅰ号 电应激 心律失常 单相动作电位 心肌损伤 

分 类 号：R285.5[医药卫生—中药学]