肥胖妇女绝经后的血脂和性激素变化  

Changes of Plasma Lipids and Sex Hormones in Obese Postmenopausal Women

作　　者：程国钧[1] 刘建立[1] 张全[1] 叶惠方[1] 王成彬[2] 沈文梅[2] 

机构地区：[1]军医进修学院妇产科 [2]军医进修学院生化科

出　　处：《军医进修学院学报》1992年第4期324-327,共4页Academic Journal of Pla Postgraduate Medical School

摘　　要：测定了166例绝经后妇女的TC、TG、HDL-C、LDL-C和E_2、FSH、LH,体重指数(BMI)大于24者为肥胖组。发现肥胖妇女的HDL-C较低,TG和TG/HDL-C较高(P<0.05),而TC、LDL-C和非肥胖者相似(P>0.05);FSH和LH较低(P<0.01),而E_2和非肥胖者相似(P>0.05);BMI和E_2是影响血脂的两个独立因素。本研究提示肥胖妇女的血脂变化可能会增加冠心病发病的危险。Obese postmenopausal women are at high risk for the development of coronary heart disease. Changes in total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), estradiol (E2), follicule-stimulating hormone (FSH) and luteinizing hormone (LH) were determined in Chinese women, aged 45 to 70 years, with YSM (years since menopause) ranging from 0.5 to 21. According to body mass index (BMI), the subjects were divided into obese group (84 cases, BMI≥24. aged 54.9 ±7.2, YSM 6.6±6.3) and non-obese group (82 cases, BMI<24, aged 56.8±5.6, YSM 7.1±5.2). The results were: 1. The obese group showed higher levels of TG, TC/HDL-C, lower levels of HDL-C, (P<0.01) but no significant different values of TC, LDL-C (P>0.05). 2. Obese group had the same E2 level as nonobese group (P>0.05), but higher level of FSH and LH (P< 0.01). 3. Plasma lipids bore relationship with E2 and BMI. BMI related positively with TG, TC/HDL-C, and negatively with HDL-C (P<0.05). E2 related positively with HDL-C, and negatively with TC, LDL-C, TC/HDL-C (P<0.05). This study exhibited that the increase of BMI and drop of E2 in postmenopausal women resulted in harmful effects on plasma lipids independently which contributed to the development of coronary heart disease.

关 键 词：绝经 肥胖 雌激素类 血脂过多 

分 类 号：R589.202[医药卫生—内分泌]