原位肝移植术后脑病的治疗  

Treatment of encephalopathy occurred after orthotopic liver transplantation

作　　者：张传永[1] 王正昕[1] 付宏[1] 张建军[1] 丁国善[1] 赵忠新[1] 付志仁[1] 

机构地区：[1]第二军医大学附属长征医院器官移植中心,上海200003

出　　处：《中国普通外科杂志》2004年第6期448-450,共3页China Journal of General Surgery

摘　　要：目的　探讨同种异体原位肝移植术后脑病可能的病因及治疗。方法回顾性分析 5 1例肝移植的临床资料。结果本组 6例患者并发了肝移植术后脑病 ,发生率为 11.8% (6/ 5 1) ,均发生在术后一月内。经应用镇静剂、多巴胺受体阻断剂 (氟哌啶醇 )治疗 ,6例患者全部治愈。结论肝移植术后脑病可能与多种因素有关 ;术前、术后的代谢紊乱 ,术中的血液动力学的异常 ,术后免疫抑制剂的应用等可能是肝移植术后脑病发生的重要因素 ;应用镇静剂、多巴胺受体阻断剂治疗肝移植术后脑病效果良好。Objective To investigate the causes and treatment of encephalopathy occurred after orthotopic liver transplantation(OLT). Methods The clinical data of consecutive 51 patients who undergoing OLT were analyzed retrospectively. Results Encephalopathy occurred in 6 cases within one month after operation.The incidence of encephalopathy after OLT was 11.8%(6/51). All the 6 cases were cured by application of sedative agent and dopamine recipient blocking agent(aloperidin). Conclusions The etiology of encephalopathy following OLT is thought to be multifactors including metabolism desturbance before and after OLT,blood dynamics alternation during opration,application of immuosuppression drug etc. Application of sedative agent and dopamine recipient blocking agent may result in ideal effects in treating the encephalopathy.

关 键 词：肝移植/副作用 脑疾病/病因学 

分 类 号：R657.3[医药卫生—外科学] R575.3[医药卫生—临床医学]