含磷手性化合物在多聚糖类手性固定相上的手性分离  

Separation of the enantiomers of chiral organic phosphonate compounds on polysaccharide chiral stationary phases

作　　者：李凌云[1] 王立新[1] 叶勇[1] 钱宝英[1] 高如瑜[1] 王琴孙[1] 

机构地区：[1]元素有机化学国家重点实验室南开大学元素有机化学研究所,天津300071

出　　处：《分析试验室》2004年第5期14-17,共4页Chinese Journal of Analysis Laboratory

摘　　要：在纤维素 三(3,5 二甲基苯基氨基甲酸酯)(ChiralcelOD)和直链淀粉 三(3,5 二甲基苯基氨基甲酸酯)(ChiralpakAD H)手性固定相上,采用高效液相色谱正相条件,分离了系列含磷手性化合物。考察了流动相中有机改性剂的种类及浓度对手性分离的影响;研究了化合物的结构与保留及对映体选择性的关系;并探讨了手性识别机理。High-performance Liquid chromatographic separation of the individual enantiomers of 9 chiral organic phosphonate compounds was obtained on cellulose and amylose tris (3,5-dimethylphenylcarbamate) derivatives (Chiralcel OD and Chiralpak AD-H) stationary phase using hexane-alcohol mobile phase. The effects of concentration and types of the organic modifiers on the enantioselectivity were investigated. The effects of structural features of the solutes on their retention behaviors and separation factor were examined. The chiral recognition mechanism was also discussed.

关 键 词：液相色谱 手性固定相 手性分离 含磷手性化合物 

分 类 号：O657.7[理学—分析化学]