越南中部京族HLA-DQA1等位基因多态性分析  

Analysis of HLA-DQA1 polymorphism of Jing nationality in central Vietnam

作　　者：陈亭平[1] 王琳琳[1] 林伟雄[1] 谢湘芝[1] 

机构地区：[1]广西医科大学第一附属医院儿科

出　　处：《中华微生物学和免疫学杂志》2004年第2期112-114,共3页Chinese Journal of Microbiology and Immunology

基　　金：广西自然科学基金资助项目 ( 0 13 5 0 2 6)

摘　　要：目的　检测和分析越南中部京族HLA DQA1等位基因的多态性。方法　应用PCR SSP方法对 2 14名健康、无血缘关系的越南中部京族儿童、青年进行HLA DQA1分型。结果　检出 10个HLA DQA1等位基因 ,频率最高的为DQA1 0 10 4 (2 5 .8% ) ,最低的是DQA1 0 6 0 1(1% )。结论　越南中部京族人的HLA DQA1等位基因分布具有民族特征 ,与中国各民族及泰国人的HLA DQA1等位基因分布有差异。Objective To analyze HLA-DQA1 polymorphism in Jing nationality of central Vietnam. Methods Applied PCR-SSP tecnique to identify the polymorphism of the HLA-DQA1 alleles of 214 healthy children and youth, unrelated individuals of Jing nationality in centre of Vietnam. Results Ten HLA-DQA1 alleles were found, of which DQA1*0104 were the most common allele with frequency of 25.8%, and lowest frequency is seen in DQA1*0601(1%). Conclusion HLA-DQA1 alleles polymorphism of Jing nationality in central Vietnam has national characteristics and is different from other Chinese and Thais.

关 键 词：越南京族 HLA-DQA1等位基因 基因多态性 人类白细胞抗原 PCR-SSP扩增技术 

分 类 号：R392[医药卫生—免疫学]